Department of Emergency Medicine, Groupe Hospitalier Broca Cochin Hôtel-Dieu, Paris, France.
Biomarkers. 2011 Dec;16(8):637-41. doi: 10.3109/1354750X.2011.620629.
Mid-regional pro-atrial natriuretic peptide (MR-proANP) increases with severity in community-acquired pneumonia (CAP). We investigated whether changes of MR-proANP correlated to bacteremia.
392 adult patients with CAP visiting emergency department from a prospective observational multicenter study.
MR-proANP levels increased in patients with positive bacteremia (92.8 pmol/L vs. 84.3 pmol/L, p = 0.04). Performance of MR-proANP to detect bacteremia (0.60) was equivalent to CRP (0.59) but less accurate than PCT (0.69).
MR-ANP poorly predicts bacteremia in CAP patients.
中段心房利钠肽前体（MR-proANP）在社区获得性肺炎（CAP）中随病情严重程度增加。我们研究了 MR-proANP 的变化是否与菌血症相关。
392 例成年 CAP 患者，来自前瞻性观察性多中心研究，就诊于急诊科。
菌血症阳性患者的 MR-proANP 水平升高（92.8 pmol/L 比 84.3 pmol/L，p=0.04）。MR-proANP 检测菌血症的性能（0.60）与 CRP（0.59）相当，但不如 PCT（0.69）准确。
MR-ANP 对 CAP 患者菌血症的预测能力较差。
