从药物基因组学知识获取到临床应用：PharmGKB 作为临床药物基因组学生物标志物资源。
From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource.
机构信息
Department of Genetics, Stanford University, 1501 S California Avenue, Palo Alto, CA 94304, USA.
出版信息
Biomark Med. 2011 Dec;5(6):795-806. doi: 10.2217/bmm.11.94.
Abstract
The mission of the Pharmacogenomics Knowledge Base (PharmGKB; www.pharmgkb.org ) is to collect, encode and disseminate knowledge about the impact of human genetic variations on drug responses. It is an important worldwide resource of clinical pharmacogenomic biomarkers available to all. The PharmGKB website has evolved to highlight our knowledge curation and aggregation over our previous emphasis on collecting primary data. This review summarizes the methods we use to drive this expanded scope of 'Knowledge Acquisition to Clinical Applications', the new features available on our website and our future goals.
摘要
Pharmacogenomics Knowledge Base（PharmGKB；www.pharmgkb.org）的使命是收集、编码和传播有关人类遗传变异对药物反应影响的知识。它是全球范围内可供所有人使用的临床药物基因组生物标志物的重要资源。PharmGKB 网站的发展重点已经从之前的收集原始数据转变为突出我们的知识管理和整合。本综述总结了我们用于推动这一“从知识获取到临床应用”扩展范围的方法、我们网站上提供的新功能以及我们的未来目标。
相似文献
1
From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource.
Biomark Med. 2011 Dec;5(6):795-806. doi: 10.2217/bmm.11.94.
2
PharmGKB and the International Warfarin Pharmacogenetics Consortium: the changing role for pharmacogenomic databases and single-drug pharmacogenetics.
Hum Mutat. 2008 Apr;29(4):456-60. doi: 10.1002/humu.20731.
3
PharmGKB, an Integrated Resource of Pharmacogenomic Knowledge.
Curr Protoc. 2021 Aug;1(8):e226. doi: 10.1002/cpz1.226.
4
PharmGKB: A worldwide resource for pharmacogenomic information.
Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23.
5
The education potential of the pharmacogenetics and pharmacogenomics knowledge base (PharmGKB).
Clin Pharmacol Ther. 2007 Oct;82(4):472-5. doi: 10.1038/sj.clpt.6100332. Epub 2007 Aug 22.
6
The PharmGKB: integration, aggregation, and annotation of pharmacogenomic data and knowledge.
Clin Pharmacol Ther. 2007 Jan;81(1):21-4. doi: 10.1038/sj.clpt.6100048.
7
Pharmacogenomics and bioinformatics: PharmGKB.
Pharmacogenomics. 2010 Apr;11(4):501-5. doi: 10.2217/pgs.10.15.
8
PharmGKB: the Pharmacogenomics Knowledge Base.
Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.
9
The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge.
Nucleic Acids Res. 2008 Jan;36(Database issue):D913-8. doi: 10.1093/nar/gkm1009. Epub 2007 Nov 21.
10
PGxMine: Text mining for curation of PharmGKB.
Pac Symp Biocomput. 2020;25:611-622.
引用本文的文献
1
A review of recent advances in gene therapy, pharmacogenomics, and genetic polymorphisms in asthma.
Mol Biol Rep. 2025 May 29;52(1):513. doi: 10.1007/s11033-025-10625-w.
2
Pharmacogenetic analysis of structural variation in the 1000 genomes project using whole genome sequences.
Sci Rep. 2024 Oct 1;14(1):22774. doi: 10.1038/s41598-024-73748-3.
3
Advice for smokers in smoking cessation clinic: a review.
Afr Health Sci. 2023 Jun;23(2):374-379. doi: 10.4314/ahs.v23i2.42.
4
The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population.
Evol Bioinform Online. 2022 Apr 24;18:11769343221095834. doi: 10.1177/11769343221095834. eCollection 2022.
5
Pharmacogenomics in the United States Community Pharmacy Setting: The Clopidogrel- Example.
Pharmgenomics Pers Med. 2021 May 18;14:569-577. doi: 10.2147/PGPM.S224894. eCollection 2021.
6
Genetic Determinants of Poor Response to Treatment in Severe Asthma.
Int J Mol Sci. 2021 Apr 20;22(8):4251. doi: 10.3390/ijms22084251.
7
Clinical pharmacogenomics in action: design, assessment and implementation of a novel pharmacogenetic panel supporting drug selection for diseases of the central nervous system (CNS).
J Transl Med. 2021 Apr 15;19(1):151. doi: 10.1186/s12967-021-02816-3.
8
Common Treatment, Common Variant: Evolutionary Prediction of Functional Pharmacogenomic Variants.
J Pers Med. 2021 Feb 16;11(2):131. doi: 10.3390/jpm11020131.
9
Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population.
PLoS Genet. 2021 Feb 18;17(2):e1009323. doi: 10.1371/journal.pgen.1009323. eCollection 2021 Feb.
10
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.
Cancers (Basel). 2020 Sep 21;12(9):2694. doi: 10.3390/cancers12092694.
本文引用的文献
1
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing.
Clin Pharmacol Ther. 2011 Oct;90(4):625-9. doi: 10.1038/clpt.2011.185. Epub 2011 Sep 7.
2
Integration and publication of heterogeneous text-mined relationships on the Semantic Web.
J Biomed Semantics. 2011 May 17;2 Suppl 2(Suppl 2):S10. doi: 10.1186/2041-1480-2-S2-S10.
3
Pharmacogenetics: from bench to byte--an update of guidelines.
Clin Pharmacol Ther. 2011 May;89(5):662-73. doi: 10.1038/clpt.2011.34. Epub 2011 Mar 16.
4
Translational aspects of genetic factors in the prediction of drug response variability: a case study of warfarin pharmacogenomics in a multi-ethnic cohort from Asia.
Pharmacogenomics J. 2012 Aug;12(4):312-8. doi: 10.1038/tpj.2011.7. Epub 2011 Mar 8.
5
PharmGKB summary: methotrexate pathway.
Pharmacogenet Genomics. 2011 Oct;21(10):679-86. doi: 10.1097/FPC.0b013e328343dd93.
6
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.
Clin Pharmacol Ther. 2011 Mar;89(3):464-7. doi: 10.1038/clpt.2010.279. Epub 2011 Jan 26.
7
PharmGKB summary: very important pharmacogene information for PTGS2.
Pharmacogenet Genomics. 2011 Sep;21(9):607-13. doi: 10.1097/FPC.0b013e3283415515.
8
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.
Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.
9
Recent progress in automatically extracting information from the pharmacogenomic literature.
Pharmacogenomics. 2010 Oct;11(10):1467-89. doi: 10.2217/pgs.10.136.
10
The BioPAX community standard for pathway data sharing.
Nat Biotechnol. 2010 Sep;28(9):935-42. doi: 10.1038/nbt.1666. Epub 2010 Sep 9.
Zotero 插件