他克莫司 0.03% 软膏治疗难治性特应性睑结膜炎。
Treatment of refractory atopic blepharoconjunctivitis with topical tacrolimus 0.03% dermatologic ointment.
机构信息
Department of Ophthalmology, Konya Training and Research Hospital, Konya, Turkey.
出版信息
J Ocul Pharmacol Ther. 2012 Feb;28(1):94-6. doi: 10.1089/jop.2011.0143. Epub 2011 Nov 21.
PURPOSE
To report a case of refractory atopic blepharoconjunctivitis (ABC) treated by using topical tacrolimus 0.03% dermatologic ointment.
METHODS
A 73-year-old man with ABC was refractory to topical corticosteroid treatment.
RESULTS
Topical tacrolimus 0.03% dermatologic ointment (Protopic; Astellas Pharma) was applied into the conjunctival fornix twice each day. Dramatic improvement of patient's symptoms was observed during the first week of therapy. Tacrolimus ointment treatment continued for 12 months. No drug-induced conjunctival hyperemia, ocular surface staining, or other adverse changes were noted secondary to the use of the topical tacrolimus ointment.
CONCLUSIONS
Topical tacrolimus 0.03% dermatologic ointment appears to be an effective treatment for ABC that is refractory to conventional therapy.
目的
报告一例难治性特应性睑结膜炎（ABC），使用他克莫司 0.03%的皮肤科软膏治疗。
方法
对一例难治性 ABC 的 73 岁男性患者，使用局部皮质类固醇治疗。
结果
患者的症状在治疗的第一周得到明显改善，每日两次将他克莫司 0.03%的皮肤科软膏（普特彼；安斯泰来制药）涂于结膜囊。他克莫司软膏治疗持续了 12 个月。使用局部他克莫司软膏没有引起结膜充血、眼表面染色或其他不良反应。
结论
他克莫司 0.03%的皮肤科软膏治疗难治性 ABC 可能是一种有效的治疗方法。
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