Kymionis George D, Goldman David, Ide Takeshi, Yoo Sonia H
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.
Cornea. 2008 Feb;27(2):228-9. doi: 10.1097/ICO.0b013e318159afbb.
To report a case of refractory giant papillary conjunctivitis (GPC) treated by using topical tacrolimus 0.03% ointment.
A 16-year-old white boy with a history of GPC was referred to our department for severe GPC with eye itching, tearing, photophobia, discharge, and blepharospasm. The patient had received previous treatments with antihistamines, mast cell stabilizers, topical corticosteroid ointments, and surgical resection-cryopexy of GPC that were ineffective.
Topical tacrolimus 0.03% ointment (Protopic; 0.5 cm) was applied into the lower fornix twice a day. An improvement of the patient's symptoms was observed during the first 5 days of therapy, and the GPC was resolved within 15 days. After 1 month of continued topical tacrolimus ointment treatment, there was no evidence of GPC. Topical tacrolimus was tapered during the next 2 months. Six months after treatment, there were no GPC findings, and no side effects were reported.
Topical tacrolimus 0.03% ointment for severe GPC, refractory to conventional therapy, appears to be an effective alternative treatment.
报告一例使用0.03%他克莫司眼膏治疗难治性巨大乳头性结膜炎（GPC）的病例。
一名16岁白人男孩，有GPC病史，因严重GPC伴眼痒、流泪、畏光、分泌物增多及眼睑痉挛转诊至我科。该患者此前接受过抗组胺药、肥大细胞稳定剂、局部皮质类固醇眼膏治疗以及GPC手术切除-冷冻治疗，但均无效。
每天两次将0.03%他克莫司眼膏（普特彼；0.5厘米）涂入下穹窿。治疗的前5天观察到患者症状有所改善，GPC在15天内消退。持续局部使用他克莫司眼膏治疗1个月后，无GPC迹象。接下来的2个月逐渐减少他克莫司的用量。治疗6个月后，无GPC表现，且未报告有副作用。
对于传统治疗无效的严重GPC，0.03%他克莫司眼膏似乎是一种有效的替代治疗方法。
