Ianysheva N Ia, Chernichenko I A, Balenko N V, Litvichenko O N, Parfenov Iu D, Antomonov M Iu, Rusakova L T
Gig Sanit. 1990 Jun(6):12-5.
Overt dependence of lung tumour development on the values of the dose administered was shown in experiments on inbred white rats under intratracheal administration of various doses of dibenz (a, h) anthracene (DBA); minimal-effect dose and maximal no-effect dose of DBA were established in the experiment. A theoretically calculated allowable dose was used to calculate MAC of the chemical under study for the ambient air 5 ng/m3 was recommended as an average 24-hour maximum allowable concentration of DBA in ambient air.
在对近交系白色大鼠进行气管内给予不同剂量二苯并(a,h)蒽(DBA)的实验中,显示出肺肿瘤发展对给药剂量值的明显依赖性;实验确定了DBA的最小效应剂量和最大无效应剂量。使用理论计算的允许剂量来计算所研究化学品在环境空气中的最大允许浓度,建议将5 ng/m3作为环境空气中DBA的平均24小时最大允许浓度。