E-选择素的多态性变体Ser128Arg与乳腺癌风险和高级别肿瘤相关。

Polymorphic variant Ser128Arg of E-Selectin is associated with breast cancer risk and high grade tumors.

作者信息

Naidu Rakesh, Har Yip C, Taib Nur A M

机构信息

School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Selangor Darul Ehsan, Malaysia.

出版信息

Onkologie. 2011;34(11):592-7. doi: 10.1159/000334060. Epub 2011 Oct 28.

DOI:10.1159/000334060

PMID:22104155

Abstract

BACKGROUND

The present study aimed to evaluate the association between the E-Selectin Ser128Arg polymorphism and breast cancer risk and clinicopathological characteristics of the patients.

MATERIALS AND METHODS

The genotypes of 387 breast cancer patients and 252 healthy women who had no history of any malignancy were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a hospital-based Malaysian population.

RESULTS

The frequency of the Arg allele was significantly (p = 0.030) higher in breast cancer patients than in healthy individuals. Women who were Ser/Arg heterozygotes (adjusted odds ratio (OR(adj)) = 1.607; 95% confidence interval (CI) = 1.008-2.564), and carriers of the Arg allele genotype (OR(adj) = 1.587; 95% CI = 1.037-2.430) or Arg allele (OR(adj) = 1.509; 95% CI = 1.040-2.189) showed a significantly increased risk of breast cancer. Patients who were carriers of the Arg allele genotype showed a significant association with poorly differentiated tumors (p = 0.002).

CONCLUSION

The Ser128Arg polymorphism might confer an increased susceptibility to breast cancer and contribute to aggressive phenotypic characteristics.

摘要

背景

本研究旨在评估E选择素Ser128Arg基因多态性与乳腺癌风险以及患者临床病理特征之间的关联。

材料与方法

在马来西亚一家医院的人群中，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测了387例乳腺癌患者和252例无任何恶性肿瘤病史的健康女性的基因型。

结果

乳腺癌患者中Arg等位基因的频率显著高于健康个体（p = 0.030）。Ser/Arg杂合子女性（调整后的优势比（OR(adj)）= 1.607；95%置信区间（CI）= 1.008 - 2.564）、Arg等位基因基因型携带者（OR(adj) = 1.587；95% CI = 1.037 - 2.430）或Arg等位基因携带者（OR(adj) = 1.509；95% CI = 1.040 - 2.189）患乳腺癌的风险显著增加。Arg等位基因基因型携带者的患者与低分化肿瘤显著相关（p = 0.002）。