Nutrition and Toxicology Research Institute Maastricht, Faculty Health, Medicine and Life Sciences, Eindhoven, The Netherlands.
Diabetes Res Clin Pract. 2012 Mar;95(3):345-51. doi: 10.1016/j.diabres.2011.10.026. Epub 2011 Nov 21.
The purpose of the present study was to distinguish the effects of both diabetes mellitus type 2 (DM2) and diabetic polyneuropathy (DPN) on mobility, muscle strength and health related quality of life (HR-QoL).
DPN patients (n=98), DM2 patients without DPN (DC) (n=39) and healthy subjects (HC) (n=19) performed isometric and isokinetic lower limb muscle strength tests. Mobility was determined by a timed up and go test (TUGT), a 6 min walk test and the physical activity scale for the elderly questionnaire. HR-QoL was determined by the SF36 questionnaire.
DPN patients had moderate polyneuropathy. In both DPN and DC patients leg muscle strength was reduced by 30-50% compared to HC. Muscle strength was correlated with mobility tests, and reduced muscle strength as well as impaired mobility were associated with a loss of HR-Qol (all p<0.05). We did not observe major differences in muscle strength, mobility (except for the TUGT, p<0.01) and HR-QoL between diabetic patients with and without DPN.
DM2 patients, with and without DPN, have decreased maximal muscle strength in the lower limbs and impaired mobility. These abnormalities are associated with a loss of HR-QoL. The additional effect of moderate DPN was small in our patients.
本研究旨在区分 2 型糖尿病（DM2）和糖尿病多发性神经病（DPN）对运动能力、肌肉力量和健康相关生活质量（HR-QoL）的影响。
DPN 患者（n=98）、无 DPN 的 DM2 患者（DC）（n=39）和健康受试者（HC）（n=19）进行等长和等速下肢肌肉力量测试。运动能力通过计时起立行走测试（TUGT）、6 分钟步行测试和老年人体力活动量表问卷进行评估。HR-QoL 通过 SF36 问卷进行评估。
DPN 患者患有中度多发性神经病。与 HC 相比，DPN 和 DC 患者的腿部肌肉力量均降低了 30-50%。肌肉力量与运动能力测试相关，肌肉力量降低以及运动能力受损与 HR-QoL 丧失相关（均 p<0.05）。我们未观察到有 DPN 和无 DPN 的糖尿病患者之间在肌肉力量、运动能力（除 TUGT 外，p<0.01）和 HR-QoL 方面存在显著差异。
有或无 DPN 的 DM2 患者下肢最大肌肉力量降低，运动能力受损。这些异常与 HR-QoL 丧失有关。在我们的患者中，中度 DPN 的额外影响较小。
