Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
Eur J Obstet Gynecol Reprod Biol. 2012 Feb;160(2):142-6. doi: 10.1016/j.ejogrb.2011.10.008. Epub 2011 Nov 21.
The clinical relevance of protein S deficiency in pregnant women remains controversial. Major debate exists regarding which parameter (total protein S antigen, free protein S antigen or functional protein S) should be evaluated in order to define protein S deficiency. The present study aimed to identify which of these parameters correlate with intrauterine growth restriction (IUGR).
A retrospective case-control study of women with IUGR (n=27) and healthy controls (n=123) in the third trimester of pregnancy.
The maternal serum of women in the IUGR group had significantly lower levels of functional and free protein S compared with the control group: 54.07 ± 24.72% vs 65.20 ± 17.95% (p<0.005) and 42.88 ± 11.01% vs 56.64 ± 13.30% (p<0.0001), respectively. No significant correlation was found between total protein S and IUGR.
Levels of functional and free protein S are correlated with IUGR.
孕妇蛋白 S 缺乏的临床相关性仍存在争议。主要的争议在于，为了定义蛋白 S 缺乏，应该评估哪个参数（总蛋白 S 抗原、游离蛋白 S 抗原或功能蛋白 S）。本研究旨在确定这些参数中哪一个与宫内生长受限（IUGR）相关。
一项回顾性病例对照研究，纳入了妊娠晚期 IUGR（n=27）和健康对照组（n=123）的妇女。
IUGR 组的母体血清中功能蛋白 S 和游离蛋白 S 的水平明显低于对照组：54.07±24.72%比 65.20±17.95%（p<0.005）和 42.88±11.01%比 56.64±13.30%（p<0.0001）。总蛋白 S 与 IUGR 之间无显著相关性。
功能蛋白 S 和游离蛋白 S 的水平与 IUGR 相关。
