Lee P I, Chang M H, Lee C Y, Hsu H Y, Chen J S, Chen P J, Chen D S
Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Republic of China.
Hepatology. 1990 Oct;12(4 Pt 1):657-60. doi: 10.1002/hep.1840120406.
During a follow-up period of 3.2 +/- 1.6 (1 to 8.6) yr, 1,087 serum specimens from 230 HBsAg carrier children were tested for hepatitis B virus markers. Dividing the serum specimens into four groups according to the status of HBeAg and hepatitis B virus DNA, the frequency of abnormally elevated ALT levels in serum was in the following order: HBeAg(+)/hepatitis B virus DNA(-) serum (60%), HBeAg(-)/hepatitis B virus DNA(+) serum (53%), HBeAg(+)/hepatitis B virus DNA(+) serum (41%), HBeAg(-)/hepatitis B virus DNA(-) serum (11%). Analysis of the data before HBeAg clearance showed that both a high serum ALT level and a low serum hepatitis B virus DNA level correlated with an imminent clearance of HBeAg. Approximately two thirds of children with serum ALT levels higher than 100 IU/L cleared HBeAg within the following year. Clearance of HBeAg occurred within the following year in 65% (13 of 20) of cases with serum hepatitis B virus DNA level less than or equal to 1,000 pg/ml, in contrast to 19% (30 of 157) of those with serum hepatitis B virus DNA level greater than 1,000 pg/ml. Among 53 children who lost HBeAg and hepatitis B virus DNA during follow-up, only nine cases did not have an identified period of abnormal serum ALT levels. For the remaining 44 children, abnormal serum ALT levels fell to normal with clearance of both HBeAg and hepatitis B virus DNA in 33 children but remained elevated in the remaining 11 cases after seroconversion.(ABSTRACT TRUNCATED AT 250 WORDS)
在3.2±1.6（1至8.6）年的随访期内，对230名HBsAg携带者儿童的1087份血清标本进行了乙肝病毒标志物检测。根据HBeAg和乙肝病毒DNA状态将血清标本分为四组，血清中ALT水平异常升高的频率依次为：HBeAg(+)/乙肝病毒DNA(-)血清（60%）、HBeAg(-)/乙肝病毒DNA(+)血清（53%）、HBeAg(+)/乙肝病毒DNA(+)血清（41%）、HBeAg(-)/乙肝病毒DNA(-)血清（11%）。对HBeAg清除前的数据进行分析显示，血清ALT水平高和血清乙肝病毒DNA水平低均与HBeAg即将清除相关。血清ALT水平高于100 IU/L的儿童中，约三分之二在次年清除了HBeAg。血清乙肝病毒DNA水平小于或等于1000 pg/ml的病例中，65%（20例中的13例）在次年清除了HBeAg，而血清乙肝病毒DNA水平大于1000 pg/ml的病例中这一比例为19%（157例中的30例）。在随访期间失去HBeAg和乙肝病毒DNA的53名儿童中，只有9例未发现血清ALT水平异常的时期。对于其余44名儿童，33名儿童在HBeAg和乙肝病毒DNA清除后血清ALT水平异常降至正常，但其余11例在血清转换后仍保持升高。（摘要截短于250字）
