使用鸡蛋白溶菌酶的酶催化直接三组分氮杂-Diels-Alder 反应。
Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme.
机构信息
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
出版信息
J Org Chem. 2012 Jan 6;77(1):200-7. doi: 10.1021/jo2016696. Epub 2011 Dec 2.
PMID:22106947
Abstract
The direct three-component aza-Diels-Alder reaction of aromatic aldehyde, aromatic amine, and 2-cyclohexen-1-one was catalyzed by hen egg white lysozyme for the first time. Under the optimized conditions investigated in this paper, the enzyme-catalyzed aza-Diels-Alder reaction gave yields up to 98% and stereoselectivity of endo/exo ratios up to 90:10.
摘要
首次报道了鸡蛋白溶菌酶催化芳香醛、芳香胺和 2-环己烯-1-酮的直接三组分氮杂-Diels-Alder 反应。在本文研究的优化条件下，酶催化的氮杂-Diels-Alder 反应最高可得到 98%的产率和高达 90:10 的内/exo 立体选择性。
Zotero 插件