年龄相关性和中风相关性骨骼肌变化：老年临床医生的综述。
Age- and stroke-related skeletal muscle changes: a review for the geriatric clinician.
机构信息
Biomechanics and Movement Science Program, University of Delaware, Newark, USA.
出版信息
J Geriatr Phys Ther. 2012 Jul-Sep;35(3):155-61. doi: 10.1519/JPT.0b013e318236db92.
Abstract
Independently, aging and stroke each have a significant negative impact on skeletal muscle, but the potential cumulative effects of aging and stroke have not been explored. Optimal interventions for individuals post stroke may include those that specifically target skeletal muscle. Addressing changes in muscles may minimize activity limitations and enhance participation post stroke. This article reviews the impact of aging and stroke on muscle morphology and composition, including fiber atrophy, reductions in muscle cross-sectional area, changes in muscle fiber distributions, and increases in intramuscular fat. Relationships between changes in muscle structure, muscle function, and physical mobility are reviewed. Clinical recommendations that preserve and enhance skeletal muscle in the aging adult and individuals post stroke are discussed. Future research directions that include systematic comparison of the differences in skeletal muscle between younger and older adults who have sustained a stroke are suggested.
摘要
独立地，衰老和中风都会对骨骼肌产生重大的负面影响，但衰老和中风的潜在累积影响尚未得到探索。中风后个体的最佳干预措施可能包括专门针对骨骼肌的干预措施。解决肌肉的变化可以最大限度地减少活动受限，并增强中风后的参与度。本文综述了衰老和中风对肌肉形态和组成的影响，包括纤维萎缩、肌肉横截面积减少、肌肉纤维分布的变化以及肌肉内脂肪的增加。还综述了肌肉结构变化与肌肉功能和身体活动能力之间的关系。讨论了针对衰老成年人和中风后个体的保持和增强骨骼肌的临床建议。还提出了未来的研究方向，包括系统比较患有中风的年轻和老年成年人之间的骨骼肌差异。
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