VCU Pauley Heart Center, Virginia Commonwealth University, VCU Medical Center, 1200 East Broad Street, Richmond, VA 23298, USA.
Heart Fail Clin. 2012 Jan;8(1):79-86. doi: 10.1016/j.hfc.2011.08.010.
Apoptosis is a key feature in the progression of heart disease. Stage B heart failure is characterized by a structurally abnormal heart in which the remodeled myocardium is prone to apoptosis. Elimination of the proapoptotic stimuli or inhibition of the apoptotic cascade could presumably rescue the myocardium and halt the progression of adverse remodeling and heart failure. In this article, the authors review the role of apoptosis (or programmed cell death) in determining the evolution of symptomatic heart failure and particularly the adverse remodeling in the aftermath of acute myocardial infarction.
细胞凋亡是心脏病进展的一个关键特征。B 期心力衰竭的特征是心脏结构异常，重塑的心肌容易发生细胞凋亡。消除促凋亡刺激或抑制细胞凋亡级联反应可能挽救心肌并阻止不良重塑和心力衰竭的进展。本文作者回顾了细胞凋亡（或程序性细胞死亡）在决定有症状心力衰竭的演变，特别是在急性心肌梗死后的不良重塑中的作用。
