University of Padua, School of Medicine, Department of Surgical & Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy.
Anticancer Res. 2011 Nov;31(11):3969-72.
In patients with parathyroid tumors and primary hyperparathyroidism (PHPT), the relationship between arterial blood pressure (BP) and both serum calcium and parathyroid hormone (PTH) is still unclear. The aim of this study was to investigate whether a correlation exists between BP and the main biochemical parameters in men with confirmed sporadic PHPT due to a solitary parathyroid adenoma. A series of 38 elderly (>64 years) men (median age 69 years, range 65-78 years) were enrolled in the study. Twenty-nine (76.3%) were asymptomatic, while 9 (23.7%) had renal diseases (i.e. renal stones, impaired renal function). The main preoperative biochemical parameters were the following: serum calcium=2.77±0.25 mmol/l, PTH=166.5±157.0 ng/l, alkaline phosphatase (ALP)=107.6±37.0 U/l, and creatinine=82.5±8.1 μmol/l. In each patient, the BP was recorded three times at 2-3 min intervals using an automatic device, and the mean values were recorded. All patients successfully underwent parathyroidectomy. As expected, there was a significant relationship between age and both systolic and diastolic BP (β=0.39, p=0.018; β=0.41, p=0.014, respectively). There was also a correlation between systolic and diastolic BP (β=0.39, p=0.01) and between serum calcium and PTH (β=0.51, p=0.008). A weak relationship (β=0.28, p=0.04) between serum calcium and creatinine was also found. However, no significant relationship between systolic or diastolic BP and serum calcium (β=0.012, p=0.94; β=0.065, p=0.71) or PTH (β=0.08, p=0.65; β=0.17, p=0.32), respectively, was observed. In conclusion, our study confirms that in men with parathyroid tumors and PHPT, the BP values are independent of both serum calcium and PTH levels.
在甲状旁腺肿瘤和原发性甲状旁腺功能亢进症（PHPT）患者中，动脉血压（BP）与血清钙和甲状旁腺激素（PTH）之间的关系尚不清楚。本研究旨在探讨在因单发甲状旁腺腺瘤而确诊的散发性 PHPT 男性中，BP 是否与主要生化参数相关。 该研究纳入了 38 名老年（>64 岁）男性（中位年龄 69 岁，范围 65-78 岁）。29 名（76.3%）患者无症状，9 名（23.7%）患有肾脏疾病（即肾结石、肾功能受损）。主要术前生化参数如下：血清钙=2.77±0.25mmol/L，PTH=166.5±157.0ng/L，碱性磷酸酶（ALP）=107.6±37.0U/L，肌酐=82.5±8.1μmol/L。在每个患者中，使用自动设备在 2-3 分钟间隔内记录三次 BP，记录平均值。所有患者均成功接受甲状旁腺切除术。正如预期的那样，年龄与收缩压和舒张压均显著相关（β=0.39，p=0.018；β=0.41，p=0.014）。收缩压和舒张压之间存在相关性（β=0.39，p=0.01），血清钙和 PTH 之间也存在相关性（β=0.51，p=0.008）。还发现血清钙和肌酐之间存在弱相关性（β=0.28，p=0.04）。然而，收缩压或舒张压与血清钙（β=0.012，p=0.94；β=0.065，p=0.71）或 PTH（β=0.08，p=0.65；β=0.17，p=0.32）之间无显著关系。总之，我们的研究证实，在甲状旁腺肿瘤和 PHPT 男性中，BP 值与血清钙和 PTH 水平无关。
