Dughera Luca, Navino Monica, Cassolino Paola, De Cento Mariella, Cacciotella Luca, Cisarò Fabio, Chiaverina Michele
Digestive Motility and Endoscopy Unit, Department of Medicine, ASO San Giovanni Battista Hospital, Via Genova 3, 10121 Turin, Italy.
Diagn Ther Endosc. 2011;2011:507157. doi: 10.1155/2011/507157. Epub 2011 Oct 24.
Since 2000, radiofrequency (RF) energy treatment has been increasingly offered as an alternative option to invasive surgical procedures for selected patients with gastroesophageal reflux disease (GERD). Out of 69 patients treated since June 2002 to December 2007 with the Stretta procedure, 56 of them reached by the end of 2010 a 48-month followup. RF treatment significantly improved heartburn scores, GERD-specific quality of life scores, and general quality of life scores at 24 and 48 months in 52 out of 56 patients (92,8%). At each control time both mean heartburn and GERD HRQL scores decreased (P = 0.001 and P = 0.003, resp.) and both mental SF-36 and physical SF-36 ameliorated (P = 0.001 and 0.05, resp.). At 48 months, 41 out of 56 patients (72,3%) were completely off PPIs. Morbidity was minimal, with only one relevant but transient complication. According to other literature data, this study shows that RF delivery to LES is safe and durably improves symptoms and quality of life in well-selected GERD patients.
自2000年以来，对于部分胃食管反流病（GERD）患者，射频（RF）能量治疗作为侵入性外科手术的替代选择越来越多地被采用。在2002年6月至2007年12月期间接受Stretta手术治疗的69例患者中，到2010年底有56例患者进行了48个月的随访。在56例患者中的52例（92.8%）中，射频治疗在24个月和48个月时显著改善了烧心评分、GERD特异性生活质量评分和总体生活质量评分。在每次对照时，平均烧心和GERD健康相关生活质量（HRQL）评分均下降（分别为P = 0.001和P = 0.003），精神SF-36和身体SF-36均有所改善（分别为P = 0.001和0.05）。在48个月时，56例患者中的41例（72.3%）完全停用了质子泵抑制剂（PPI）。并发症发生率极低，仅有1例相关但短暂的并发症。根据其他文献数据，本研究表明，对精心挑选的GERD患者进行LES射频治疗是安全的，且能持久改善症状和生活质量。
