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Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.

作者信息

Hill B T, Bailey B D, White J C, Goldman I D

出版信息

Cancer Res. 1979 Jul;39(7 Pt 1):2440-6.

PMID:221104
Abstract
摘要

相似文献

1
Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.两株L5178Y淋巴母细胞系对4-氨基抗叶酸和叶酸化合物的转运特性，其中一株甲氨蝶呤转运受损。
Cancer Res. 1979 Jul;39(7 Pt 1):2440-6.
2
Rescue of human lymphoid cells from the effects of methotrexate in vitro.体外挽救甲氨蝶呤对人淋巴细胞的影响
Cancer Res. 1978 Nov;38(11 Pt 1):3847-53.
3
[Biochemical aspects of folate transport].[叶酸转运的生化方面]
Usp Sovrem Biol. 1979 Nov-Dec;88(3):353-66.
4
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.体外培养的人源和鼠源肿瘤细胞中各种叶酸类似物的总多聚谷氨酰化及细胞毒性的类似差异。
Cancer Res. 1985 Apr;45(4):1488-95.
5
Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles.L1210白血病细胞对叶酸化合物的载体介导转运关系：质膜囊泡中表现出具有不同动力学特性的多种进入途径的证据。
J Membr Biol. 1983;75(1):11-20. doi: 10.1007/BF01870795.
6
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.由于还原型叶酸载体介导的转运受损而对甲氨蝶呤高度耐药的小鼠白血病细胞系中，对5,10-二去氮四氢叶酸的敏感性完全保守。
Clin Cancer Res. 2000 Aug;6(8):3304-11.
7
Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes.
Cancer Res. 1980 Mar;40(3):573-8.
8
Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.甲氨蝶呤和氨基蝶呤的8-脱氮类似物在小鼠体内的细胞毒性、摄取、聚谷氨酸形成及抗白血病作用
Cancer Res. 1988 Mar 15;48(6):1481-8.
9
Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.与小鼠小肠不同成熟阶段上皮细胞中二氢叶酸还原酶水平的变化形成对比的是，体外叶酸类似物转运具有相似的特征。
Cancer Res. 1984 Nov;44(11):5204-11.
10
Membrane transport of antifolates as a critical determinant of drug cytotoxicity.抗叶酸药物的膜转运作为药物细胞毒性的关键决定因素。
Adv Exp Med Biol. 1977;84:85-113. doi: 10.1007/978-1-4684-3279-4_5.

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Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells.进入恶性胶质瘤细胞后经历细胞内再活化的白蛋白 - 甲氨蝶呤前药类似物。
Pharmaceutics. 2021 Dec 28;14(1):71. doi: 10.3390/pharmaceutics14010071.
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HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity.组蛋白去乙酰化酶抑制剂：剖析对抗肿瘤异质性的作用机制
Cancers (Basel). 2021 Jul 16;13(14):3575. doi: 10.3390/cancers13143575.
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Roles Of EAAT1, DHFR, And Fetuin-A In The Pathogenesis, Progression And Prognosis Of Chondrosarcoma.
EAAT1、二氢叶酸还原酶（DHFR）和胎球蛋白-A在软骨肉瘤发病机制、进展及预后中的作用
Onco Targets Ther. 2019 Oct 14;12:8411-8420. doi: 10.2147/OTT.S222426. eCollection 2019.
4
A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer.A到I RNA编辑上调乳腺癌中的人二氢叶酸还原酶。
J Biol Chem. 2017 Mar 24;292(12):4873-4884. doi: 10.1074/jbc.M117.775684. Epub 2017 Feb 10.
5
Isolation and characterization of a dihydrofolate reductase gene mutation in methotrexate-resistant Drosophila cells.甲氨蝶呤抗性果蝇细胞中二氢叶酸还原酶基因突变的分离与鉴定
Gene Expr. 1996;6(4):231-9.
6
Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.胸苷酸合成酶基因在一株对N10-炔丙基-5,8-二去氮叶酸耐药的人白血病MOLT-3细胞系中扩增，该细胞系在蝶酰谷氨酸中培养时出现这种情况，但在亚叶酸中培养时未出现。
J Cancer Res Clin Oncol. 1996;122(11):659-64. doi: 10.1007/BF01209028.
7
Clinical pharmacokinetics and pharmacology of trimetrexate.三甲曲沙的临床药代动力学与药理学
Clin Pharmacokinet. 1994 Mar;26(3):190-200. doi: 10.2165/00003088-199426030-00003.
8
Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.培养的人头部和颈部鳞状细胞癌中甲氨蝶呤耐药性的发展。
Proc Natl Acad Sci U S A. 1984 May;81(9):2873-7. doi: 10.1073/pnas.81.9.2873.
9
Genomic hypomethylation and far-5' sequence alterations are associated with carcinogen-induced activation of the hamster thymidine kinase gene.基因组低甲基化和远5'端序列改变与致癌物诱导的仓鼠胸苷激酶基因激活有关。
Mol Cell Biol. 1986 Sep;6(9):3023-33. doi: 10.1128/mcb.6.9.3023-3033.1986.
10
Phase II trial of 10 deaza-aminopterin in patients with bladder cancer.
Invest New Drugs. 1986;4(2):171-4. doi: 10.1007/BF00194598.