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成功治疗一名重症联合免疫缺陷儿童的播散性卡介苗病

Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency.

作者信息

Bacalhau Sílvia, Freitas Cristina, Valente Rosalina, Barata Deolinda, Neves Conceição, Schäfer Katrin, Lubatschofski Annelie, Schulz Ansgar, Neves João Farela

机构信息

Pediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, Portugal.

出版信息

Case Rep Med. 2011;2011:527569. doi: 10.1155/2011/527569. Epub 2011 Oct 24.

DOI:10.1155/2011/527569
PMID:22110512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3202142/
Abstract

In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.

摘要

在高负担国家，新生儿会接种卡介苗（BCG）以预防严重的结核分枝杆菌感染。由于原发性免疫缺陷儿童可能发生危及生命的播散性卡介苗病，因此在非高负担国家应重新定义结核病疫苗接种策略。我们报告了1例患有X连锁重症联合免疫缺陷（SCID）并发生播散性卡介苗病的患者病例，并着重介绍了所采取的具体策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/c2fd8c22fa0d/CRIM2011-527569.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/3e1495b71cac/CRIM2011-527569.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/5396dd591f8b/CRIM2011-527569.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/c2fd8c22fa0d/CRIM2011-527569.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/3e1495b71cac/CRIM2011-527569.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/5396dd591f8b/CRIM2011-527569.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5f/3202142/c2fd8c22fa0d/CRIM2011-527569.003.jpg

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2
Assistance of next-generation sequencing for diagnosis of disseminated Bacillus Calmette-Guerin disease with X-SCID in an infant: a case report and literature review.二代测序辅助诊断 X-连锁严重联合免疫缺陷病婴儿播散卡介苗病：病例报告及文献复习。
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J Clin Immunol. 2022 Jan;42(1):195-198. doi: 10.1007/s10875-021-01143-y. Epub 2021 Oct 7.
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