Wang Jue, Wang Fen Wei, Hemstreet George P
Department of Internal Medicine, Section of Oncology-Hematology, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA.
Prostate Cancer. 2011;2011:216169. doi: 10.1155/2011/216169. Epub 2010 Jul 20.
Objective. The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC) patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database. Methods & Results. Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified. The mean age was 70 ± 11 years old. 82.8% of the patients had poorly or undifferentiated histology grade. 13.9% patients presented with metastatic disease. The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively. Using multivariate Cox proportional hazard model, younger age (40-50 versus age >70 yrs, P = .01), advanced tumor stage (distant versus local/regional, P = .02), and earlier diagnosis year (before 1995 versus after 1995, P = .01) were predictors of worse cancer specific survival. Conclusions. Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival. This information could be useful when counseling these patients and emphasizes the need for new strategies and molecular-based therapeutic approaches for younger patients with SRPC.
目的。本研究旨在通过对国家监测、流行病学和最终结果（SEER）数据库的分析，探讨印戒细胞前列腺癌（SRPC）患者的流行病学、自然史、治疗模式以及长期生存的预测因素。方法与结果。在1980年至2004年期间，共识别出93例经病理证实的SRPC患者。平均年龄为70±11岁。82.8%的患者组织学分级为低分化或未分化。13.9%的患者出现转移性疾病。1年、3年和5年的癌症特异性生存率分别为94.6%、89.6%和83.8%。使用多变量Cox比例风险模型，较年轻的年龄（40 - 50岁与>70岁，P = 0.01）、晚期肿瘤分期（远处转移与局部/区域，P = 0.02）以及较早的诊断年份（1995年之前与1995年之后，P = 0.01）是癌症特异性生存较差的预测因素。结论。尽管癌症治疗更积极，但年轻的SRPC患者癌症特异性生存更差。这些信息在为这些患者提供咨询时可能有用，并强调需要为年轻的SRPC患者制定新的策略和基于分子的治疗方法。
