Santiago Casiano Mónica, Paulo Malavé Liza M, Fahme Eduardo, Maldonado Rivera Sandra N, González Omayra, Cáceres Perkins William, Hernán Martínez José
Department of Internal Medicine, San Juan City Hospital, San Juan, Puerto Rico.
Bol Asoc Med P R. 2011 Apr-Jun;103(2):77-9.
We report a case of a young female patient presenting with a high serum beta-HCG levels, amenorrhea, nausea and anemia which mimicked pregnancy followed by upper gastrointestinal bleeding. A gastric tumor was shown on endoscopy. Histopathologic evaluation revealed Primary Gastric Choriocarcinoma (PGC). The patient was treated with three cycles of standard nongestational choriocarcinoma chemotherapy. Tumor persistence was evidenced by CT Scans and high serum beta-HCG levels. The patient died approximately six months after diagnosis. Our case report suggest that PGC is a highly aggressive tumor that is often associated with liver and lungs metastasis without evidence of pelvic organ abnormality and is associated with some hormonal effects, such as amenorrhea, anemia, nausea and vomiting mimicking pregnancy in young adult female
我们报告一例年轻女性患者,其血清β-HCG水平升高、闭经、恶心且贫血,类似妊娠,随后出现上消化道出血。内镜检查显示胃部有肿瘤。组织病理学评估显示为原发性胃绒毛膜癌(PGC)。该患者接受了三个周期的标准非妊娠性绒毛膜癌化疗。CT扫描和高血清β-HCG水平证明肿瘤持续存在。患者在诊断后约六个月死亡。我们的病例报告表明,原发性胃绒毛膜癌是一种高度侵袭性肿瘤,常伴有肝肺转移,而盆腔器官无异常迹象,且与一些激素效应有关,如闭经、贫血、恶心和呕吐,在年轻成年女性中类似妊娠。