III Department of Pediatrics, The Polish Mother's Memorial Hospital, Research Institute, Lodz, Poland.
Adv Med Sci. 2011;56(2):180-5. doi: 10.2478/v10039-011-0048-5.
HCV chronic infection still presents a very serious epidemiological and clinical problem. Apart from its cytopathic effect on liver parenchyma, its detrimental effect on lipid and carbohydrate metabolism has recently been emphasized. The aim of the study was to assess lipid and carbohydrate parameters in children with chronic HCV-related hepatitis.
MATERIAL/METHODS: The study comprised 41 children with chronic hepatitis C (CHC) aged between 7 and 18 years, and 30 healthy controls. The anthropometric measurements of the subjects were taken, and, after overnight fasting, serum glucose, insulin, total bilirubin, AST, ALT, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride levels were investigated. The HOMA IR insulin resistance index was also calculated.
The values for mean body mass index (BMI), glucose, insulin, bilirubin, LDL-cholesterol, HDL-cholesterol, triglycerides, HDL/C index and HOMA IR levels did not differ significantly between the two groups. AST and ALT were significantly higher in the control group. The serum levels of cholesterol and LDL-cholesterol showed a tendency toward lower values in the control group. We found positive correlation between serum levels of insulin and HOMA IR with staging (respectively r=0.336, P < 0.04 and r=0.386, P < 0.02).
In children with CHC and a relatively short duration of the disease, lipid and glucose disorders are not observed. Correlations between insulin and HOMA IR with staging suggest the ability of HCV to contribute to fibrosis through interference with glucose metabolism.
HCV 慢性感染仍然是一个非常严重的流行病学和临床问题。除了对肝实质的细胞病变作用外，其对脂质和碳水化合物代谢的有害影响最近也受到了重视。本研究的目的是评估慢性丙型肝炎相关肝炎患儿的脂质和碳水化合物参数。
材料/方法：本研究包括 41 名年龄在 7 至 18 岁的慢性丙型肝炎（CHC）患儿和 30 名健康对照者。对受试者进行了人体测量学测量，在禁食过夜后，检测了血清葡萄糖、胰岛素、总胆红素、AST、ALT、总胆固醇、LDL-胆固醇、HDL-胆固醇和甘油三酯水平。还计算了 HOMA IR 胰岛素抵抗指数。
两组间平均体重指数（BMI）、葡萄糖、胰岛素、胆红素、LDL-胆固醇、HDL-胆固醇、甘油三酯、HDL/C 指数和 HOMA IR 水平无显著差异。AST 和 ALT 在对照组中显著升高。胆固醇和 LDL-胆固醇的血清水平在对照组中呈下降趋势。我们发现血清胰岛素和 HOMA IR 与分期呈正相关（分别 r=0.336，P<0.04 和 r=0.386，P<0.02）。
在 CHC 患儿中，在疾病相对较短的时间内，未观察到脂质和葡萄糖紊乱。胰岛素和 HOMA IR 与分期之间的相关性表明 HCV 通过干扰葡萄糖代谢有助于纤维化的能力。
