Clinical Research Centre, MD11, 10 Medical Drive, Singapore, 117597, Singapore.
Aust Crit Care. 2012 May;25(2):78-90. doi: 10.1016/j.aucc.2011.10.001. Epub 2011 Nov 22.
Less invasive methods of determining cardiac output are now readily available. Using indicator dilution technique, for example has made it easier to continuously measure cardiac output because it uses the existing intra-arterial line. Therefore gone is the need for a pulmonary artery floatation catheter and with it the ability to measure left atrial and left ventricular work indices as well the ability to monitor and measure a mixed venous saturation (SvO(2)).
The aim of this paper is to put forward the notion that SvO(2) provides valuable information about oxygen consumption and venous reserve; important measures in the critically ill to ensure oxygen supply meets cellular demand. In an attempt to portray this, a simplified example of the septic patient is offered to highlight the changing pathophysiological sequelae of the inflammatory process and its importance for monitoring SvO(2).
SvO(2) monitoring, it could be argued, provides the gold standard for assessing arterial and venous oxygen indices in the critically ill. For the bedside ICU nurse the plethora of information inherent in SvO(2) monitoring could provide them with important data that will assist in averting potential problems with oxygen delivery and consumption. However, it has been suggested that central venous saturation (ScvO(2)) might be an attractive alternative to SvO(2) because of its less invasiveness and ease of obtaining a sample for analysis. There are problems with this approach and these are to do with where the catheter tip is sited and the nature of the venous admixture at this site. Studies have shown that ScvO(2) is less accurate than SvO(2) and should not be used as a sole guiding variable for decision-making. These studies have demonstrated that there is an unacceptably wide range in variance between ScvO(2) and SvO(2) and this is dependent on the presenting disease, in some cases SvO(2) will be significantly lower than ScvO(2).
Whilst newer technologies have been developed to continuously measure cardiac output, SvO(2) monitoring is still an important adjunct to clinical decision-making in the ICU. Given the information that it provides, seeking alternatives such as ScvO(2) or blood samples obtained from femorally placed central venous lines, can unnecessarily lead to inappropriate treatment being given or withheld. Instead when using ScvO(2), trending of this variable should provide clinical determinates that are useable for the bedside ICU nurse, remembering that in most conditions SvO(2) will be approximately 16% lower.
现在有更微创的方法来确定心输出量。例如,使用指示剂稀释技术,可以更容易地连续测量心输出量,因为它使用现有的动脉内导管。因此,不再需要肺动脉漂浮导管,也就无法测量左心房和左心室工作指数,以及监测和测量混合静脉饱和度(SvO₂)。
本文旨在提出一个观点,即 SvO₂ 提供了有关氧消耗和静脉储备的有价值信息;这是危重病患者中的重要措施,以确保氧气供应满足细胞需求。为了说明这一点,提供了一个简单的脓毒症患者示例,以突出炎症过程的病理生理后果的变化及其对 SvO₂ 监测的重要性。
可以说,SvO₂ 监测为评估危重病患者的动脉和静脉氧指数提供了金标准。对于床边 ICU 护士来说,SvO₂ 监测中固有的大量信息可以为他们提供重要数据,以帮助避免潜在的氧气输送和消耗问题。然而,有人认为中心静脉饱和度(ScvO₂)可能是一种有吸引力的替代方法,因为它的侵入性较小,并且更容易获得样本进行分析。但这种方法存在一些问题,这些问题与导管尖端的位置以及该位置的静脉混合有关。研究表明,ScvO₂ 不如 SvO₂ 准确,不应作为决策的唯一指导变量。这些研究表明,ScvO₂ 和 SvO₂ 之间的差异很大,并且这种差异取决于所呈现的疾病,在某些情况下,SvO₂ 将明显低于 ScvO₂。
虽然已经开发了新技术来连续测量心输出量,但 SvO₂ 监测仍然是 ICU 临床决策的重要辅助手段。考虑到它提供的信息,寻找替代方法,如 ScvO₂ 或从股静脉放置的中心静脉导管获得的血液样本,可能会导致不必要地给予或拒绝不当治疗。相反,当使用 ScvO₂ 时,对该变量的趋势分析应该为床边 ICU 护士提供可用的临床指标,记住在大多数情况下,SvO₂ 将降低约 16%。