Miyagi Y
Bull Tokyo Med Dent Univ. 1979 Jun;26(2):81-4.
Guanosine 3'5'-cyclic monophosphate (cGMP) in the plasma of normal persons and patients with lung or breast cancer and other kinds of neoplasma or other diseases was determined using radioimmunoassay. In comparison with normal persons, significant elevation occurred in the cGMP in the plasma of patients with various kinds of cancer or renal insufficiency. The average cGMP values in the plasma of eight normal persons, 16 patients with lung cancer, 16 patients with breast cancer, five patients with oesophagus cancer, three patients with liver cancer, three patients with stomach cancer, ten patients with renal insufficiency and two patients with myocardial infarction, were respectively 3.46, 9.05, 5.39, 5.42, 7.33, 11.66, 19.55, and 8.0 pmol per ml of plasma. There was no elevation in the cGMP in the plasma of the patients with other diseases studied.
采用放射免疫分析法测定了正常人和肺癌、乳腺癌及其他类型肿瘤或其他疾病患者血浆中的3',5'-环磷酸鸟苷（cGMP）。与正常人相比，各类癌症患者或肾功能不全患者血浆中的cGMP显著升高。8名正常人、16名肺癌患者、16名乳腺癌患者、5名食管癌患者、3名肝癌患者、3名胃癌患者、10名肾功能不全患者和2名心肌梗死患者血浆中的cGMP平均水平分别为每毫升血浆3.46、9.05、5.39、5.42、7.33、11.66、19.55和8.0皮摩尔。在所研究的其他疾病患者血浆中，cGMP没有升高。
