Silva Margarida, Carvalho Nuno, Teixeira Ana, Nogueira Graça, Menezes Isabel, Ferreira Rui, Maymone-Martins Fernando, Anjos Rui
Serviço de Cardiologia Pediátrica, Hospital de Santa Cruz, CHLO, Carnaxide, Portugal.
Rev Port Cardiol. 2011 Dec;30(12):891-6. doi: 10.1016/j.repc.2011.10.005. Epub 2011 Nov 22.
A coronary fistula is a connection between one of the coronary arteries and a cardiac chamber or great artery. It is a rare defect and usually occurs in isolation. Two-dimensional echocardiography has an important role in diagnosis but coronary or CT angiography is essential to delineate the anatomy. Surgery is the traditional therapeutic approach but percutaneous closure is now the recommended method, with excellent results and few complications in experienced centers.
We describe our experience with percutaneous treatment of 15 coronary fistulas in 12 patients between 1996 and 2011. Eight (67%) were male and median age was 25 years. The most frequent symptoms were murmur and/or fatigue. All fistulas were congenital. Five patients (42%) had concomitant cardiac disease: pulmonary atresia with intact ventricular septum (1), patent ductus arteriosus (1), ostium secundum atrial septal defect (1), stenotic bicuspid aortic valve (1), and critical pulmonary stenosis operated in the neonatal period (1). Three patients had two fistulas, while the others had a single lesion. All fistulas were hemodynamically significant. They originated in the territory of the right coronary (10), left coronary (3) and circumflex (2), draining into the right ventricle (5), pulmonary artery (6), right atrium (2) coronary sinus (1) and left ventricle (1). Embolization materials included standard coils, controlled-release coils, microcoils (standard, GDC or IDC) and an Amplatzer(®) duct occluder.
Embolization was achieved in all patients. There was no mortality. One patient with a large fistula and a very small right coronary artery distally to the origin of the fistula had a right ventricular infarction. In three patients there were minor complications: inadvertent coil embolization, recovered in the same procedure (1), transient arrhythmia (1) and femoral pseudo-aneurysm (1). In a mean follow-up of 4.9 years (one month to 14 years), there were no procedure-related complications. Echocardiographic and/or angiographic control showed complete and permanent occlusion in ten patients and minimal residual flow in two patients through small collaterals with no hemodynamic significance.
Percutaneous embolization represents an effective form of treatment for selected coronary fistulas. A wide range of embolization devices must be available to ensure the best therapeutic approach.
冠状动脉瘘是指冠状动脉之一与心腔或大动脉之间的连接。它是一种罕见的先天性缺陷,通常单独发生。二维超声心动图在诊断中起着重要作用,但冠状动脉造影或CT血管造影对于明确其解剖结构至关重要。手术是传统的治疗方法,但目前经皮封堵是推荐的方法,在经验丰富的中心效果良好且并发症较少。
我们描述了1996年至2011年间对12例患者的15例冠状动脉瘘进行经皮治疗的经验。8例(67%)为男性,中位年龄为25岁。最常见的症状是杂音和/或疲劳。所有瘘均为先天性。5例患者(42%)合并有其他心脏病:室间隔完整的肺动脉闭锁(1例)、动脉导管未闭(1例)、继发孔房间隔缺损(1例)、狭窄的二叶式主动脉瓣(1例)以及新生儿期接受手术治疗的重度肺动脉狭窄(1例)。3例患者有两个瘘,其余患者为单个病变。所有瘘均具有血流动力学意义。它们起源于右冠状动脉供血区域(10例)、左冠状动脉(3例)和回旋支(2例),引流至右心室(5例)、肺动脉(6例)、右心房(2例)、冠状窦(1例)和左心室(1例)。栓塞材料包括标准弹簧圈、控释弹簧圈、微弹簧圈(标准型、GDC或IDC)以及Amplatzer®动脉导管封堵器。
所有患者均成功实现栓塞。无死亡病例。1例瘘较大且瘘口远端右冠状动脉非常细小的患者发生了右心室梗死。3例患者出现轻微并发症:术中弹簧圈意外栓塞,在同一手术过程中取出(1例)、短暂性心律失常(1例)和股动脉假性动脉瘤(1例)。平均随访4.9年(1个月至14年),无手术相关并发症。超声心动图和/或血管造影检查显示,10例患者完全永久性封堵,2例患者通过无血流动力学意义的小侧支有微量残余血流。
经皮栓塞是治疗特定冠状动脉瘘的一种有效方法。必须备有多种栓塞装置以确保最佳治疗方案。