Honnas C M, Liskey C C, Meagher D M, Brown D, Luck E E
Veterinary Medical Teaching Hospital, University of California, Davis 95616.
J Am Vet Med Assoc. 1990 Sep 15;197(6):756-8.
A 24-year-old horse had a malignant melanoma of the right forefoot. Because surgical excision of the melanoma was incomplete, as determined by histologic examination of the excised tissue margins, the tumor margins were injected with a matrix therapeutic implant containing cis-diamminedichloroplatinum, epinephrine, and purified bovine collagen matrix. The foot healed and the horse remained clinically free of disease for 26 months before recurrence of malignant melanoma. Surgical exploration of the digit revealed extensive involvement of the foot, and the horse was euthanatized.
一匹24岁的马右前足患恶性黑色素瘤。由于根据切除组织边缘的组织学检查确定黑色素瘤的手术切除不完全，遂在肿瘤边缘注射了一种含有顺二氯二氨铂、肾上腺素和纯化牛胶原基质的基质治疗植入物。足部愈合，这匹马在恶性黑色素瘤复发前临床上无疾病状态持续了26个月。对该趾进行手术探查发现足部广泛受累，于是对这匹马实施了安乐死。
