Congenital ichthyosis in a llama.

A 1-month-old male cria was examined because of diffuse hyperkeratosis and conjunctivitis that had existed since birth. The mucocutaneous junction of the nostrils as well as the neck, coronary bands, and axillary and inguinal regions were the most severely affected areas. Orthokeratosis involving the epidermis and follicular infundibula was observed on skin biopsy specimens. Electron microscopy revealed 4 to 6 granular layers and inter- and intracellular vacuolation in the stratum corneum; diagnosis of ichthyosis was established.