聚合物降解的逆反应：通过二硫键断裂形成原位交联凝胶。

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage.

机构信息

Network of Excellence for Functional Biomaterials, National University of Ireland Galway, IDA Business Park, Galway, Ireland.

出版信息

Chem Commun (Camb). 2012 Jan 14;48(4):585-7. doi: 10.1039/c1cc16538k. Epub 2011 Nov 23.

DOI:10.1039/c1cc16538k

PMID:22113516

Abstract

In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing "one pot" hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

摘要

与通常在聚合物结构中包含二硫键以促进生物降解的方式相反，我们设计了一种自固化的“一锅法”超支化聚合物，能够在富含肿瘤组织的还原条件下形成交联凝胶。