Bagshaw Kyle R, Hanenbaum Curt L, Carbone Erica J, Lo Kevin W H, Laurencin Cato T, Walker Joseph, Nair Lakshmi S
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Ther Deliv. 2015 Feb;6(2):165-76. doi: 10.4155/tde.14.95.
Acute and chronic pain control is a significant clinical challenge that has been largely unmet. Local anesthetics are widely used for the control of post-operative pain and in the therapy of acute and chronic pain. While a variety of approaches are currently used to prolong the duration of action of local anesthetics, an optimal strategy to achieve neural blockage for several hours to days with minimal toxicity has yet to be identified. Several drug delivery systems such as liposomes, microparticles and nanoparticles have been investigated as local anesthetic delivery vehicles to achieve prolonged anesthesia. Recently, injectable responsive hydrogels raise significant interest for the localized delivery of anesthetic molecules. This paper discusses the potential of injectable hydrogels to prolong the action of local anesthetics.
急慢性疼痛控制是一项重大的临床挑战，目前在很大程度上尚未得到解决。局部麻醉药广泛用于控制术后疼痛以及急慢性疼痛的治疗。虽然目前有多种方法可用于延长局部麻醉药的作用持续时间，但尚未找到一种能以最小毒性实现数小时至数天神经阻滞的最佳策略。已经研究了几种药物递送系统，如脂质体、微粒和纳米颗粒，作为局部麻醉药的递送载体以实现延长麻醉效果。最近，可注射响应性水凝胶在麻醉分子的局部递送方面引起了极大关注。本文讨论了可注射水凝胶延长局部麻醉药作用的潜力。
