周环化 prenylation：通过 Claisen 重排进行肽修饰。
Pericyclic prenylation: peptide modification through a Claisen rearrangement.
机构信息
Department of Medicinal Chemistry and Molecular Pharmacology, The Purdue University Center for Cancer Research, West Lafayette, IN 47906, USA.
出版信息
Chembiochem. 2011 Dec 16;12(18):2723-6. doi: 10.1002/cbic.201100612. Epub 2011 Nov 24.
LynF prenylates, but the prenyl migrates: Schmidt and co-workers have demonstrated that LynF from Lyngbya aestuarii is a reverse O-prenyl transferase. However, a forward C-prenylated product is obtained through a non-enzymatic Claisen rearrangement. The elucidation of this unprecedented two-step process is a significant contribution to our understanding of the biosynthesis of complex macrocyclic peptides.
LynF 进行 prenyl 化，但 prenyl 发生迁移：Schmidt 及其同事已经证明，来自 Lyngbya aestuarii 的 LynF 是一种反向 O-prenyl 转移酶。然而，通过非酶促的 Claisen 重排得到了正向 C-prenylated 产物。对这一前所未有的两步过程的阐明，是对我们理解复杂大环肽生物合成的重大贡献。
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