Nather A, Balasubramaniam P, Bose K
Department of Orthopaedic Surgery, National University Hospital, Singapore.
J Bone Joint Surg Br. 1990 Sep;72(5):830-4. doi: 10.1302/0301-620X.72B5.2211765.
Four different experiments were performed to study the healing of a large, non-vascularised, diaphyseal, bone segment in adult cats. In the first experiment, a 4 cm segment of tibia with its periosteum was excised and replaced in its bed. The other experiments were similar, except that in the second, the periosteum of the segment was removed, in the third its medullary canal was blocked with a Silastic rod, and in the last group the segment was isolated from its muscle bed by a Silastic sheet. The reparative processes were quantified by estimating the resorption index, the cortical new bone formation index, the callus encasement index, and the osteocyte count. Bone resorption and apposition occurred in the segment even when the periosteum was absent or the medullary canal was blocked, with osseous union at both ends by eight to 12 weeks, provided the segment was not isolated from its muscle bed. Thus, the muscle bed played a significant role in these reparative processes.
进行了四项不同的实验，以研究成年猫中一段大的、无血管的骨干骨段的愈合情况。在第一个实验中，切除一段4厘米长的胫骨及其骨膜，然后将其放回原位。其他实验类似，不同之处在于，在第二个实验中，骨段的骨膜被去除；在第三个实验中，其髓腔用一根硅橡胶棒堵塞；在最后一组实验中，骨段通过一块硅橡胶片与肌肉床分离。通过估计吸收指数、皮质新骨形成指数、骨痂包裹指数和骨细胞计数来量化修复过程。即使骨膜缺失或髓腔被堵塞，骨段中仍会发生骨吸收和骨沉积，在8至12周时两端实现骨性愈合，前提是骨段未与肌肉床分离。因此，肌肉床在这些修复过程中发挥了重要作用。
