Fletcher Mark C, Spera Joseph F
Dent Clin North Am. 2012 Jan;56(1):95-111, viii. doi: 10.1016/j.cden.2011.09.001.
This article provides a brief review of the acute pain mechanism as it relates to the effects of a surgical insult. A brief understanding of the physiologic modulation of acute pain establishes a rational framework for the concept of preemptive and postoperative analgesia. A brief review of commonly used analgesic agents is presented. Research in pain management and new drug development is ongoing as new concepts in neurophysiology and pharmacology are being elucidated.
本文简要回顾了与手术创伤影响相关的急性疼痛机制。对急性疼痛生理调节的简要理解为超前镇痛和术后镇痛的概念建立了一个合理的框架。文中还简要介绍了常用的镇痛药物。随着神经生理学和药理学新概念的阐明，疼痛管理和新药开发的研究正在进行中。
