Mason R A, Newton G B, Cassel W, Maneksha F, Giron F
Department of Surgery, State University of New York, Stony Brook School of Medicine.
J Cardiovasc Surg (Torino). 1990 Jul-Aug;31(4):442-7.
The perioperative course of 144 consecutive patients undergoing aortic reconstructive surgery was studied to assess the potential benefit of employing a combined epidural and light general anesthesia technique. A group of 67 patients had general anesthesia alone (GA), while in the group of 77 remaining patients, a combined epidural and general anesthesia (Epi-GA) was employed. The two groups were similar in regards to age, medical risk factors, preoperative assessment of cardiac and pulmonary function, and type of surgical reconstruction. There was no significant difference in the anesthetic, operative time, or operative fluid requirements between the two groups. There was a lower rate pressure product in the Epi-GA group during aortic cross clamping (P less than 0.05). More patients in the GA group required a prolonged ventilatory support (P less than 0.05) and a high parenteral narcotic administration (P less than 0.025) during the first 48 hours. While the mortality rate was similar for the two groups (3.0% for GA group vs 5.2% for Epi-GA group), there was a higher percent of postoperative pulmonary complications observed in the GA group (7.6%) compared to the Epi-GA group (2.6%). By facilitating early extubation and a decreased need for systemic narcotics in the early postoperative period, Epi-GA may be beneficial in the high risk pulmonary patient undergoing aortic reconstruction.
对144例连续接受主动脉重建手术患者的围手术期过程进行研究,以评估采用硬膜外麻醉与浅全身麻醉联合技术的潜在益处。一组67例患者仅接受全身麻醉(GA),而其余77例患者采用硬膜外麻醉与全身麻醉联合(Epi-GA)。两组在年龄、医疗风险因素、术前心肺功能评估以及手术重建类型方面相似。两组之间在麻醉、手术时间或手术液体需求量方面无显著差异。Epi-GA组在主动脉阻断期间的心率血压乘积较低(P<0.05)。GA组更多患者在最初48小时内需要延长通气支持(P<0.05)以及大量胃肠外给予麻醉剂(P<0.025)。虽然两组死亡率相似(GA组为3.0%,Epi-GA组为5.2%),但GA组术后肺部并发症发生率(7.6%)高于Epi-GA组(2.6%)。通过促进早期拔管以及减少术后早期对全身麻醉剂的需求,Epi-GA对于接受主动脉重建手术的高危肺部疾病患者可能有益。