白细胞介素2受体α基因多态性与多发性硬化症风险：一项荟萃分析。
Interleukin 2 receptor α gene polymorphism and risk of multiple sclerosis: a meta-analysis.
作者信息
Wang L-M, Zhang D-M, Xu Y-M, Sun S-L
机构信息
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
出版信息
J Int Med Res. 2011;39(5):1625-35. doi: 10.1177/147323001103900505.
This meta-analysis studied the association between interleukin 2 receptor α (IL2RA) gene polymorphisms rs2104286 and rs12722489 and susceptibility to multiple sclerosis (MS). Case-control genetic association studies published before January 2011 were retrieved from the PubMed and EMBASE databases and the Cochrane Library. Eight studies comprising 13 569 patients and 23 435 controls met the selection criteria for meta-analysis of the IL2RA rs2104286 polymorphism. Using a fixed-effects model, the T allele and the TT and TT + TC genotypes of the IL2RA rs2104286 polymorphism were found to be associated with MS. Five studies comprising 5643 patients and 6415 controls met the selection criteria for meta-analysis of the IL2RA rs12722489 polymorphism. Using a fixed-effects model, the C allele and the CC genotype of the IL2RA rs12722489 polymorphism were found to be associated with MS but the CC + CT genotype was not. It was concluded that both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to MS.
这项荟萃分析研究了白细胞介素2受体α（IL2RA）基因多态性rs2104286和rs12722489与多发性硬化症（MS）易感性之间的关联。从PubMed、EMBASE数据库和Cochrane图书馆检索了2011年1月之前发表的病例对照基因关联研究。八项研究共纳入13569例患者和23435例对照，符合对IL2RA rs2104286多态性进行荟萃分析的选择标准。采用固定效应模型，发现IL2RA rs2104286多态性的T等位基因以及TT和TT + TC基因型与MS相关。五项研究共纳入5643例患者和6415例对照，符合对IL2RA rs12722489多态性进行荟萃分析的选择标准。采用固定效应模型，发现IL2RA rs12722489多态性的C等位基因以及CC基因型与MS相关，但CC + CT基因型与MS无关。研究得出结论，IL2RA基因多态性rs2104286和rs12722489均与MS易感性增加有关。
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