Nanjangud Gouri, Amarillo Ina, Rao P Nagesh
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, 2-226 Rehab Center, 1000 Veteran Avenue, Los Angeles, CA 90024, USA.
Clin Lab Med. 2011 Dec;31(4):785-811, xi. doi: 10.1016/j.cll.2011.07.007. Epub 2011 Oct 21.
Conventional cytogenetics in conjunction with Fluorescence in Situ Hybridization (FISH) continues to remain an important and integral component in the diagnosis and management of solid tumors. The ability to effectively detect the vast majority of clinically relevant chromosomal aberrations with a rapid-to-acceptable turnaround time makes them the most cost-effective screening/detection tool currently available in modern pathology. In this review, we describe a representative set of solid tumors in which chromosomal analysis and/or FISH plays a significant role in the routine clinical management of solid tumors.
传统细胞遗传学与荧光原位杂交（FISH）相结合，仍然是实体瘤诊断和管理中的重要组成部分。能够在快速到可接受的周转时间内有效检测绝大多数临床相关染色体畸变，使其成为现代病理学中目前最具成本效益的筛查/检测工具。在本综述中，我们描述了一组具有代表性的实体瘤，其中染色体分析和/或FISH在实体瘤的常规临床管理中发挥着重要作用。
