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[西班牙内科服务中因慢性阻塞性肺疾病急性加重住院的老年患者的临床特征与治疗。ECCO研究]

[Clinical profile and treatment of elderly patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease in Spanish Internal Medicine services. ECCO study].

作者信息

Boixeda Ramon, Almagro Pedro, Díez Jesús, Custardoy Juan, López García Francisco, San Román Terán Carlos, Recio Jesús, Soriano Joan B

机构信息

Servicio de Medicina Interna, Hospital de Mataró, Departamento de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Med Clin (Barc). 2012 Apr 28;138(11):461-7. doi: 10.1016/j.medcli.2011.05.030. Epub 2011 Nov 25.

DOI:10.1016/j.medcli.2011.05.030
PMID:22118975
Abstract

BACKGROUND AND OBJECTIVE

Hospitalizations for chronic obstructive pulmonary disease (COPD) occur mostly in elderly patients. We describe the characteristics and treatment of elderly patients hospitalized for COPD in Internal Medicine Services, compared with the younger age group.

PATIENTS AND METHODS

Observational, prospective, multicenter study. We compared the differences between patients older than 80 years and the rest regarding comorbidity, severity of COPD, previous admissions, length of stay and treatment prescribed. Comorbidity was assessed by the Charlson index and a questionnaire was designed for this purpose.

RESULTS

We included 398 subjects, 353 men (89%) with a mean age of 73.7 years (SD 8.8), of whom about 107 (26.9%) were older than 80 years. These patients had less severe COPD according to the GOLD classification (P<.02). Although the overall morbidity was similar in both groups, elderly patients had greater presence of arrhythmias (P<.01), left ventricular hypertrophy (P<.01) and received more diuretics (P<.05). Dyspnoea, length of stay and mortality were similar between both populations. Home oxygen therapy prior to and use of inhaled corticosteroids and oxygen therapy was lower in older patients, even when they were clinically indicated.

CONCLUSIONS

A quarter of patients hospitalized for COPD in Internal Medicine Services are over 80 years. Although they present less obstruction, they have a similar degree of dyspnea, increased cardiac morbidity and their treatment is less consistent with the recommendations of the guidelines.

摘要

背景与目的

慢性阻塞性肺疾病(COPD)患者住院情况大多发生在老年患者中。我们描述了在内科病房因COPD住院的老年患者的特征及治疗情况,并与年轻患者组进行比较。

患者与方法

观察性、前瞻性、多中心研究。我们比较了80岁以上患者与其他患者在合并症、COPD严重程度、既往住院史、住院时间及所开治疗药物方面的差异。合并症通过查尔森指数进行评估,并为此设计了一份问卷。

结果

我们纳入了398名受试者,其中353名男性(89%),平均年龄73.7岁(标准差8.8),其中约107名(26.9%)年龄超过80岁。根据全球慢性阻塞性肺疾病倡议(GOLD)分级,这些患者的COPD病情较轻(P<0.02)。尽管两组的总体发病率相似,但老年患者心律失常(P<0.01)、左心室肥厚(P<0.01)的发生率更高,且使用利尿剂更多(P<0.05)。两组患者的呼吸困难、住院时间和死亡率相似。老年患者在临床有指征时,之前接受家庭氧疗以及吸入糖皮质激素和氧疗的比例较低。

结论

在内科病房因COPD住院的患者中有四分之一年龄超过80岁。尽管他们的气道阻塞较轻,但呼吸困难程度相似,心脏发病率增加,且他们的治疗与指南建议的一致性较低。

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