Institute of Physiology, IN:spired, Developmental Physiology and Developmental Neuroscience, Center for Physiological Medicine, Medical University of Graz, Austria.
Res Dev Disabil. 2012 Mar-Apr;33(2):461-6. doi: 10.1016/j.ridd.2011.10.007. Epub 2011 Nov 24.
To assess whether there are qualitatively deviant characteristics in the early vocalizations of children with Rett syndrome, we had 400 native Austrian-German speakers listen to audio recordings of vocalizations from typically developing girls and girls with Rett syndrome. The audio recordings were rated as (a) inconspicuous, (b) conspicuous or (c) not able to decide between (a) and (b). The results showed that participants were accurate in differentiating the vocalizations of typically developing children compared to children with Rett syndrome. However, the accuracy for rating verbal behaviors was dependent on the type of vocalization with greater accuracy for canonical babbling compared to cooing vocalizations. The results suggest a potential role for the use of rating child vocalizations for early detection of Rett syndrome. This is important because clinical criteria related to speech and language development remain important for early identification of Rett syndrome.
为了评估雷特综合征儿童早期发声是否存在定性异常特征，我们让 400 名奥地利-德国母语者聆听正常发育女孩和雷特综合征女孩的发声录音。这些录音被评为 (a) 不显眼，(b) 显眼或 (c) 无法在 (a) 和 (b) 之间做出决定。结果表明，参与者能够准确地区分正常发育儿童和雷特综合征儿童的发声。然而，对于言语行为的评分准确性取决于发声类型，与咕咕发声相比，对规范的咿呀学语的评分更准确。结果表明，对儿童发声进行评分可能有助于早期发现雷特综合征。这很重要，因为与言语和语言发展相关的临床标准仍然是早期识别雷特综合征的重要依据。
