Center for Dental Care of Persons with Disabilities - CAOE, School of Dentistry of Araçatuba, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
Res Dev Disabil. 2012 Mar-Apr;33(2):499-505. doi: 10.1016/j.ridd.2011.10.015. Epub 2011 Nov 24.
The purpose of this study was to analyze the alpha-amylase (sAA) and cortisol levels in children with Global developmental delay (GDD) before and after dental treatment and its association with the children's behavior during treatment. The morning salivary cortisol levels and activity of sAA of 33 children with GDD were evaluated before and after dental treatment and were compared to 19 healthy children. The behavior of children with GDD during dental care was assessed by the Frankl scale. Children with GDD showed lower levels of sAA activity than healthy children, but this result was not significant. The salivary cortisol levels were similar between GDD and healthy children. GDD children showed increased levels of sAA (but not cortisol) prior to the dental treatment as compared to the post-treatment phase. GDD children who showed less favorable behavior during dental care had higher levels of sAA and salivary cortisol than GDD children with more favorable behavior, but only the sAA results were significant. In conclusion, GDD children show hyperactivity of the SNS-axis in anticipation of dental treatment which indicates the need for strategies to reduce their anxiety levels before and during dental care.
本研究旨在分析患有全面发育迟缓（GDD）的儿童在牙科治疗前后唾液α-淀粉酶（sAA）和皮质醇水平及其与治疗期间儿童行为的关系。评估了 33 名患有 GDD 的儿童在牙科治疗前后的清晨唾液皮质醇水平和 sAA 活性，并与 19 名健康儿童进行了比较。使用 Frankl 量表评估 GDD 儿童在牙科护理期间的行为。与健康儿童相比，GDD 儿童的 sAA 活性水平较低，但差异无统计学意义。GDD 和健康儿童的唾液皮质醇水平相似。与治疗后相比，GDD 儿童在牙科治疗前 sAA（而非皮质醇）水平升高。与行为更有利的 GDD 儿童相比，行为更不利的 GDD 儿童的 sAA 和唾液皮质醇水平更高，但只有 sAA 结果具有统计学意义。总之，GDD 儿童在接受牙科治疗前表现出交感神经系统（SNS）轴的过度活跃，这表明需要在牙科治疗前和治疗期间采取策略来降低他们的焦虑水平。
