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[德国的泌尿生殖系统结核:诊断与治疗]

[Genitourinary tuberculosis in Germany: diagnosis and treatment].

作者信息

Lenk S

机构信息

Privatpraxis für Urologie und Andrologie, Müggelwerderweg 31, 12589 Berlin, Deutschland.

出版信息

Urologe A. 2011 Dec;50(12):1619-27. doi: 10.1007/s00120-011-2700-x.

DOI:10.1007/s00120-011-2700-x
PMID:22120191
Abstract

Genitourinary tuberculosis (GUTB) usually results from the reactivation of old, dormant tuberculous diseases by pathogens of the Mycobacterium tuberculosis complex. The diagnosis of tuberculosis of the urinary tract is based on the case history, the finding of pyuria in the absence of infection as judged by culture on routine media and by radiological imaging. A positive yellow egg culture and/or histological analysis of biopsy specimens possibly combined with the polymerase chain reaction (PCR) is still required in most patients to establish a definitive diagnosis of GUTB. Antituberculous drug treatment is based on an initial 2 month intensive phase with three or four drugs daily followed by a 4 month continuation phase with only two drugs. Surgery as a treatment option in GUTB might be indicated in complicated urinary tuberculosis. After antituberculous treatment of GUTB a follow-up surveillance over 5 years is recommended. Although the incidence of GUTB in Germany is relatively low, it is still necessary to impart and deepen scientific knowledge of the diagnosis and therapy of GUTB.

摘要

泌尿生殖系统结核(GUTB)通常是由结核分枝杆菌复合群病原体激活陈旧的、潜伏的结核疾病所致。泌尿系统结核的诊断基于病史、在常规培养基上培养未发现感染迹象时发现脓尿以及影像学检查结果。大多数患者仍需通过阳性的黄色卵培养基培养和/或活检标本的组织学分析,可能结合聚合酶链反应(PCR)来确诊GUTB。抗结核药物治疗基于初始2个月的强化期,每日使用三种或四种药物,随后是4个月的持续期,仅使用两种药物。对于复杂的泌尿系统结核,手术可能是GUTB的一种治疗选择。GUTB抗结核治疗后,建议进行5年的随访监测。尽管德国GUTB的发病率相对较低,但仍有必要传授和深化GUTB诊断和治疗的科学知识。

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本文引用的文献

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Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system.应用自动化 GeneXpert MTB/RIF 系统快速检测肺外结核。
J Clin Microbiol. 2011 Apr;49(4):1202-5. doi: 10.1128/JCM.02268-10. Epub 2011 Jan 26.
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Epidemiology of urogenital tuberculosis worldwide.全球泌尿生殖系统结核的流行病学
Int J Urol. 2008 Sep;15(9):827-32. doi: 10.1111/j.1442-2042.2008.02099.x. Epub 2008 Jul 10.
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Robert Koch and the discovery of the tubercle bacillus: the challenge of HIV and tuberculosis 125 years later.
Ther Adv Infect Dis. 2014 Apr;2(2):61-70. doi: 10.1177/2049936114528173.
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Genitourinary tuberculosis: historical and basic science review: past and present.泌尿生殖系统结核:历史与基础科学回顾:过去与现在
Cent European J Urol. 2012;65(4):182-7. doi: 10.5173/ceju.2012.04.art1. Epub 2012 Dec 11.
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Best practice in the diagnosis and management of urogenital tuberculosis.泌尿生殖系统结核病的诊断和管理最佳实践。
Ther Adv Urol. 2013 Jun;5(3):143-51. doi: 10.1177/1756287213476128.
罗伯特·科赫与结核杆菌的发现:125年后的艾滋病毒与结核病挑战
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Post-mortem compared with clinical diagnosis of genito-urinary tuberculosis in adult males.成年男性泌尿生殖系统结核的尸检与临床诊断对比
J Urol. 1949 Jun;61(6):1078-88. doi: 10.1016/S0022-5347(17)69186-9.
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Demographic characteristics of patients with extrapulmonary tuberculosis in Germany.德国肺外结核患者的人口统计学特征。
Eur Respir J. 2008 Jan;31(1):99-105. doi: 10.1183/09031936.00020607. Epub 2007 Sep 5.
6
125 years after Robert Koch's discovery of the tubercle bacillus: the new XDR-TB threat. Is "science" enough to tackle the epidemic?在罗伯特·科赫发现结核杆菌125年后:广泛耐药结核病的新威胁。“科学”足以应对这一流行病吗?
Eur Respir J. 2007 Mar;29(3):423-7. doi: 10.1183/09031936.00001307.
7
Use of the BACTEC Mycobacteria Growth Indicator Tube 960 automated system for recovery of Mycobacteria from 9,558 extrapulmonary specimens, including urine samples.使用BACTEC分枝杆菌生长指示管960自动化系统从9558份肺外标本(包括尿液样本)中分离分枝杆菌。
J Clin Microbiol. 2006 Nov;44(11):4014-7. doi: 10.1128/JCM.00829-06. Epub 2006 Sep 27.
8
Clinical relevance of nucleic acid amplification test for patients with urinary tuberculosis during antituberculosis treatment.核酸扩增试验在抗结核治疗期间对泌尿生殖系统结核患者的临床相关性。
J Infect Chemother. 2005 Dec;11(6):300-2. doi: 10.1007/s10156-005-0414-y.
9
EAU guidelines for the management of genitourinary tuberculosis.欧洲泌尿外科学会泌尿生殖系统结核管理指南。
Eur Urol. 2005 Sep;48(3):353-62. doi: 10.1016/j.eururo.2005.03.008. Epub 2005 Mar 16.
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