Lenk S
Privatpraxis für Urologie und Andrologie, Müggelwerderweg 31, 12589 Berlin, Deutschland.
Urologe A. 2011 Dec;50(12):1619-27. doi: 10.1007/s00120-011-2700-x.
Genitourinary tuberculosis (GUTB) usually results from the reactivation of old, dormant tuberculous diseases by pathogens of the Mycobacterium tuberculosis complex. The diagnosis of tuberculosis of the urinary tract is based on the case history, the finding of pyuria in the absence of infection as judged by culture on routine media and by radiological imaging. A positive yellow egg culture and/or histological analysis of biopsy specimens possibly combined with the polymerase chain reaction (PCR) is still required in most patients to establish a definitive diagnosis of GUTB. Antituberculous drug treatment is based on an initial 2 month intensive phase with three or four drugs daily followed by a 4 month continuation phase with only two drugs. Surgery as a treatment option in GUTB might be indicated in complicated urinary tuberculosis. After antituberculous treatment of GUTB a follow-up surveillance over 5 years is recommended. Although the incidence of GUTB in Germany is relatively low, it is still necessary to impart and deepen scientific knowledge of the diagnosis and therapy of GUTB.
泌尿生殖系统结核(GUTB)通常是由结核分枝杆菌复合群病原体激活陈旧的、潜伏的结核疾病所致。泌尿系统结核的诊断基于病史、在常规培养基上培养未发现感染迹象时发现脓尿以及影像学检查结果。大多数患者仍需通过阳性的黄色卵培养基培养和/或活检标本的组织学分析,可能结合聚合酶链反应(PCR)来确诊GUTB。抗结核药物治疗基于初始2个月的强化期,每日使用三种或四种药物,随后是4个月的持续期,仅使用两种药物。对于复杂的泌尿系统结核,手术可能是GUTB的一种治疗选择。GUTB抗结核治疗后,建议进行5年的随访监测。尽管德国GUTB的发病率相对较低,但仍有必要传授和深化GUTB诊断和治疗的科学知识。