Chen Shuai, Guan Shaokang, Li Wen, Wang Huanxin, Chen Juan, Wang Yisheng, Wang Haitao
Materials Research Centre, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450002, China.
J Biomed Mater Res B Appl Biomater. 2012 Feb;100(2):533-43. doi: 10.1002/jbm.b.31982. Epub 2011 Nov 28.
Composite coatings with hydroxyapatite (HA), octacalcium phosphate (OCP) in electrochemical deposition (ED) layers and MgO, Mg3 (PO4 )2 in microarc oxidation (MAO) layers were prepared by ED and MAO on Mg-Zn-Ca alloy to improve the corrosion resistance and bone response. Substrates and coated samples were implanted in the femur shaft of rabbits to observe in vivo degradation behavior during 50 weeks. Results showed that the degradation rate of the substrates was much faster than the coated at 8, 12 weeks and became close to the coated at 18 weeks postoperatively. The composite coatings prevented the substrate from rapid release of magnesium ions at the interface and gradually degraded at the same time. The composite coatings induced more newly formed bone tissue and faster bone response. Overall, reduced degradation rate and improved bone response were achieved by the composite coatings. Thus, the composite coatings on Mg-Zn-Ca alloy are promising for clinical application in the future.
通过电化学沉积（ED）和微弧氧化（MAO）工艺在Mg-Zn-Ca合金上制备了复合涂层，其中ED层含有羟基磷灰石（HA）、八钙磷酸酯（OCP），MAO层含有MgO、Mg3(PO4)2，以提高其耐腐蚀性和骨反应性。将基体和涂层样品植入兔股骨干中，观察50周内的体内降解行为。结果表明，术后8周和12周时，基体的降解速率比涂层快得多，而在18周时与涂层接近。复合涂层阻止了基体在界面处快速释放镁离子，同时自身逐渐降解。复合涂层诱导形成了更多新的骨组织，骨反应更快。总体而言，复合涂层降低了降解速率，改善了骨反应。因此，Mg-Zn-Ca合金上的复合涂层在未来临床应用中具有广阔前景。
