Singh Navdeep, Batra Uma, Kumar Kamal, Ahuja Neeraj, Mahapatro Anil
Department of Metallurgical and Materials Engineering, Punjab Engineering College, Chandigarh, 160012, India.
Department of Mechanical Engineering, Punjab Engineering College, Chandigarh, 160012, India.
Bioact Mater. 2022 May 15;19:717-757. doi: 10.1016/j.bioactmat.2022.05.009. eCollection 2023 Jan.
Mg and its alloys evince strong candidature for biodegradable bone implants, cardiovascular stents, and wound closing devices. However, their rapid degradation rate causes premature implant failure, constraining clinical applications. Bio-functional surface coatings have emerged as the most competent strategy to fulfill the diverse clinical requirements, besides yielding effective corrosion resistance. This article reviews the progress of biodegradable and advanced surface coatings on Mg alloys investigated in recent years, aiming to build up a comprehensive knowledge framework of coating techniques, processing parameters, performance measures in terms of corrosion resistance, adhesion strength, and biocompatibility. Recently developed conversion and deposition type surface coatings are thoroughly discussed by reporting their essential therapeutic responses like osteogenesis, angiogenesis, cytocompatibility, hemocompatibility, anti-bacterial, and controlled drug release towards in-vitro and in-vivo study models. The challenges associated with metallic, ceramic and polymeric coatings along with merits and demerits of various coatings have been illustrated. The use of multilayered hybrid coating comprising a unique combination of organic and inorganic components has been emphasized with future perspectives to obtain diverse bio-functionalities in a facile single coating system for orthopedic implant applications.
镁及其合金在可生物降解的骨植入物、心血管支架和伤口闭合装置方面显示出很强的应用潜力。然而，它们快速的降解速率会导致植入物过早失效，从而限制了其临床应用。除了能提供有效的耐腐蚀性外，生物功能表面涂层已成为满足各种临床需求的最有效策略。本文综述了近年来研究的镁合金可生物降解及先进表面涂层的进展，旨在建立一个关于涂层技术、工艺参数、耐腐蚀性、附着力和生物相容性等性能指标的综合知识框架。通过报道它们对体外和体内研究模型的基本治疗反应，如成骨、血管生成、细胞相容性、血液相容性、抗菌和控释药物等，对最近开发的转化型和沉积型表面涂层进行了深入讨论。阐述了金属、陶瓷和聚合物涂层相关的挑战以及各种涂层的优缺点。强调了使用包含有机和无机成分独特组合的多层混合涂层，并展望了其未来前景，以便在用于骨科植入应用的简易单一涂层系统中获得多种生物功能。
