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米替福新成功治疗多灶性皮肤利什曼病。

Successful treatment of multifocal cutaneous leishmaniasis with miltefosine.

作者信息

Madke Bhushan, Kharkar Vidya, Chikhalkar Siddhi, Mahajan Sunanda, Khopkar Uday

机构信息

Department of Dermatology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.

出版信息

Indian J Dermatol. 2011 Sep-Oct;56(5):587-90. doi: 10.4103/0019-5154.87165.

Abstract

We report a 48-year-old immunocompetent male, resident of Central India, who presented with slowly progressive asymptomatic multiple red lesions on different parts of body. On enquiry, the patient gave history of travel to Middle East 6 months back. Examination showed 10 crusted erythematous indurated plaques and nodules over forearms, left leg, right index finger, left wrist and dorsa of both feet. Histopathological examination of tissue biopsy showed multiple intracellular as well as extracellular leishmania donovan bodies. Keeping in mind the higher rate of side effects to pentavalent antimony, we treated this patient with oral miltefosine 50 mg bid and the lesions showed complete resolution over 4 months of therapy.

摘要

我们报告了一名48岁免疫功能正常的男性,居住在印度中部,他身上不同部位出现了缓慢进展的无症状多发性红色病变。经询问,患者有6个月前前往中东的旅行史。检查发现前臂、左腿、右手食指、左手腕和双足背部有10个结痂的红斑性硬结斑块和结节。组织活检的组织病理学检查显示有多个细胞内和细胞外杜氏利什曼原虫小体。考虑到五价锑的副作用发生率较高,我们用口服米替福新50毫克,每日两次治疗该患者,病变在4个月的治疗后完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f18d/3221233/664dbc97cb87/IJD-56-587-g001.jpg

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