直接酰胺的形成来自未激活的羧酸和胺。
Direct amide formation from unactivated carboxylic acids and amines.
机构信息
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
出版信息
Chem Commun (Camb). 2012 Jan 18;48(5):666-8. doi: 10.1039/c1cc15210f. Epub 2011 Nov 28.
PMID:22121499
Abstract
The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
摘要
未活化的羧酸与胺的直接偶联可以在甲苯中于 110°C 下进行，无需催化剂。使用简单的锆催化剂，负载量为 5mol%，只需 4 小时即可形成酰胺。
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