Rush Alzheimer's Disease Center, Department of Neurological Science, Rush University Medical Center, Chicago, IL 60612, USA.
Aging Cell. 2012 Apr;11(2):228-33. doi: 10.1111/j.1474-9726.2011.00777.x. Epub 2011 Dec 29.
The cholesteryl ester transfer protein (CETP) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late-onset Alzheimer's disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinical-pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry. Our results suggest that the CETP I405V polymorphism was associated with a faster rather than a slower rate of decline in cognition over time, and an increased risk of incident AD. This finding is consistent with data showing that the CETP I405V is associated with increased neuritic plaque density at autopsy.
胆固醇酯转移蛋白（CETP）基因在调节胆固醇稳态中发挥着重要作用，是晚发性阿尔茨海默病（AD）的候选易感基因。最近的研究结果表明，CETP I405V 多态性（rs5882）与记忆衰退速度较慢和痴呆发病风险较低有关。本研究利用美国两项正在进行的与衰老和痴呆相关的临床病理学队列研究（宗教秩序研究和记忆与衰老项目）的数据，评估了 CETP I405V 多态性（rs5882）与欧洲血统的 1300 多名参与者认知能力下降和 AD 发病风险的相关性。我们的结果表明，CETP I405V 多态性与认知能力随时间的下降速度加快有关，而不是下降速度较慢，并且 AD 的发病风险增加。这一发现与尸检显示 CETP I405V 与神经突斑块密度增加的数据一致。
