Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
J Alzheimers Dis. 2018;64(s1):S161-S189. doi: 10.3233/JAD-179939.
The Religious Orders Study and Rush Memory and Aging Project are both ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease (AD).
To summarize progress over the past five years and its implications for understanding neurodegenerative diseases.
Participants in both studies are older adults who enroll without dementia and agree to detailed longitudinal clinical evaluations and organ donation. The last review summarized findings through the end of 2011. Here we summarize progress and study findings over the past five years and discuss new directions for how these studies can inform on aging and AD in the future.
We summarize 1) findings on the relation of neurobiology to clinical AD; 2) neurobiologic pathways linking risk factors to clinical AD; 3) non-cognitive AD phenotypes including motor function and decision making; 4) the development of a novel drug discovery platform.
Complexity at multiple levels needs to be understood and overcome to develop effective treatments and preventions for cognitive decline and AD dementia.
宗教秩序研究和拉什记忆与衰老项目都是正在进行的关于衰老和阿尔茨海默病（AD）的纵向临床病理队列研究。
总结过去五年的进展及其对理解神经退行性疾病的意义。
两项研究的参与者均为年龄较大的成年人，他们在没有痴呆的情况下参加，并同意进行详细的纵向临床评估和器官捐赠。上一次综述总结了截至 2011 年底的研究结果。在这里，我们总结了过去五年的进展和研究结果，并讨论了这些研究在未来如何为衰老和 AD 提供信息的新方向。
我们总结了 1）神经生物学与临床 AD 的关系的发现；2）将风险因素与临床 AD 联系起来的神经生物学途径；3）包括运动功能和决策制定在内的非认知 AD 表型；4）开发新的药物发现平台。
需要理解和克服多层次的复杂性，以开发针对认知衰退和 AD 痴呆的有效治疗和预防方法。
