载脂蛋白 E 基因多态性与晚发性阿尔茨海默病的关联。
Association of clusterin gene polymorphisms with late-onset Alzheimer's disease.
机构信息
Department of Neurology, Indiana University School of Medicine, Indianapolis, USA.
出版信息
Dement Geriatr Cogn Disord. 2011;32(3):198-201. doi: 10.1159/000331276. Epub 2011 Nov 26.
BACKGROUND/AIMS: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects.
METHODS
LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion.
RESULTS
Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk.
CONCLUSION
The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.
背景/目的：一些研究表明载脂蛋白 J [簇蛋白 (CLU)，apoJ] 在阿尔茨海默病 (AD) 的发病机制中起作用。在这项研究中，我们调查了 CLU 内 rs11136000 和 rs9331888 多态性在迟发性散发性 AD (LOAD) 患者和非痴呆患者中的作用。
方法
分析 LOAD 患者和对照组。采用标准 PCR 结合不同的限制性内切酶消化法检测 rs11136000 和 rs9331888 的基因型。
结果
尽管这两个多态性的基因型频率没有显著差异，但 CG 单倍型与 LOAD 风险显著增加相关。
结论
CLU 基因的 rs11136000 和 rs9331888 多态性与 LOAD 相关。
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