Department of Neurology, School of Medicine, Jagiellonian University, ul. Botaniczna 3, Cracow, Poland.
Dement Geriatr Cogn Disord. 2011;31(6):417-23. doi: 10.1159/000329571. Epub 2011 Jul 13.
The relationship between different paraoxonase (PON) gene polymorphisms and the risk of Alzheimer's disease (AD) was studied several times and the results were controversial.
We investigated the association of 4 single-nucleotide polymorphisms (SNPs) of the PON1 (M55L; Q192R; -161C/T) and the PON2 (C311S) genes that were shown to affect the risk of sporadic AD. We studied 360 Caucasian cases with late-onset AD and 354 nondemented controls.
No significant differences were observed between the studied PON SNPs and AD risk. The results did not change after stratification of the apolipoprotein E status. Meta-analyses of studies in Caucasians assessing the associations between the PON1 M55L, -161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found.
Our results suggest that the studied PON1 and PON2 polymorphisms are not associated with late-onset AD.
不同的对氧磷酶（PON）基因多态性与阿尔茨海默病（AD）风险之间的关系已经被多次研究，但结果存在争议。
我们研究了与散发性 AD 风险相关的 PON1（M55L；Q192R；-161C/T）和 PON2（C311S）基因的 4 个单核苷酸多态性（SNP）之间的关联。我们研究了 360 例高加索裔晚发性 AD 病例和 354 例非痴呆对照者。
在研究的 PON SNP 与 AD 风险之间未观察到显著差异。在载脂蛋白 E 状态分层后，结果没有改变。对评估 PON1 M55L、-161C/T 和 Q192R SNP 与 AD 风险之间关联的高加索裔人群研究进行了荟萃分析，未发现关联。
我们的结果表明，研究的 PON1 和 PON2 多态性与晚发性 AD 无关。
