Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Crit Care Clin. 2012 Jan;28(1):57-76, vi. doi: 10.1016/j.ccc.2011.09.003.
Sepsis, severe sepsis, and septic shock impose a growing economic burden on health care systems globally. This article first describes the epidemiology of sepsis within the United States and internationally. It then reviews costs associated with sepsis and its management in the United States and internationally, including general cost sources in intensive care, direct costs of sepsis, and indirect costs of the burden of illness imposed by sepsis. Finally, it examines the cost-effectiveness of sepsis interventions, focusing on formal cost-effectiveness analyses of nosocomial sepsis prevention strategies, drotrecogin alfa (activated),and integrated sepsis protocols.
脓毒症、严重脓毒症和脓毒性休克给全球医疗系统带来的经济负担日益加重。本文首先描述了美国和国际范围内脓毒症的流行病学情况。然后，本文回顾了美国和国际范围内与脓毒症及其治疗相关的费用，包括重症监护的一般费用来源、脓毒症的直接费用，以及脓毒症带来的疾病负担的间接费用。最后，本文考察了脓毒症干预措施的成本效益，重点关注院内脓毒症预防策略、活化型打替考拉宁和脓毒症综合方案的正式成本效益分析。
