Lemos Elkin V, De la Hoz Restrepo Fernando, Alvis Nelson, Quevedo Elkin, Cañon Oscar, León Yazmin
Universidad Nacional de Colombia, Bogotá, Colombia.
Rev Panam Salud Publica. 2011 Oct;30(4):287-94.
Compare mortality in multidrug-susceptible Acinetobacter baumannii infected patients and multidrug-resistant A. baumannii-infected patients hospitalized in intensive care units (ICUs) in Colombia.
A prospective, observational, and multicenter study. A total of 165 patients admitted to the participating ICUs from April 2006 to April 2010 were included. On day 14 and day 30 of hospitalization, mortality in multidrug-resistant patients with clinical isolates of A. baumannii was compared with that in multidrug-susceptible patients.
Of the 165 adult patients who had health care-associated infections (HAI) caused by A. baumannii, multidrug-susceptible bacteria were found in 62 patients and multidrug-resistant bacteria in 103. Statistically significant differences in mortality on day 14 of hospitalization in the ICU were not found. On the other hand, significant differences (P < 0.05) in mortality on day 30 of hospitalization were observed between patients with multidrug-resistant isolates and those with multidrug-susceptible isolates. This difference was maintained when the patients' risk factors were evaluated by multivariate analysis.
The presence of multidrug resistance is the primary risk factor for mortality in patients with HAI caused by A. baumannii in Colombian ICUs.
比较哥伦比亚重症监护病房（ICU）中感染多重耐药鲍曼不动杆菌患者与感染多重敏感鲍曼不动杆菌患者的死亡率。
一项前瞻性、观察性多中心研究。纳入2006年4月至2010年4月期间入住参与研究的ICU的165例患者。在住院第14天和第30天，比较鲍曼不动杆菌临床分离株为多重耐药的患者与多重敏感的患者的死亡率。
在165例由鲍曼不动杆菌引起医疗保健相关感染（HAI）的成年患者中，62例患者分离出多重敏感菌，103例患者分离出多重耐药菌。未发现ICU住院第14天死亡率有统计学显著差异。另一方面，在住院第30天，多重耐药菌分离株患者与多重敏感菌分离株患者的死亡率存在显著差异（P<0.05）。在通过多变量分析评估患者的危险因素时，这种差异依然存在。
在哥伦比亚ICU中，多重耐药是鲍曼不动杆菌引起的HAI患者死亡的主要危险因素。
