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儿茶酚氧位甲基转移酶 Val108/158Met 多态性与乳腺癌风险：叙利亚的病例对照研究。

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.

机构信息

Department of Pharmacology, Cancer Research Lab, Faculty of Pharmacy, University of Aleppo, University Street, Aleppo, Syria,

出版信息

Breast Cancer. 2013 Jan;20(1):62-6. doi: 10.1007/s12282-011-0309-y. Epub 2011 Nov 29.

DOI:10.1007/s12282-011-0309-y
PMID:22124994
Abstract

BACKGROUND

Catechol-O-methyltransferase (COMT) inactivates catechol estrogens by methylation and thus may play a protective role against mutations induced by estrogen metabolites. In this study we investigated the relationship between the Vall58Met polymorphism in the COMT gene and breast cancer risk in a population-based case control study in Syria.

METHODS

We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the association between the functional genetic Val158Met polymorphism in the COMT gene and female breast cancer risk.

RESULTS

There was no significant overall association between the COMT genotype and individual susceptibility to breast cancer.

CONCLUSIONS

Our data suggest that there may be no overall association between the COMT genotype and breast cancer.

摘要

背景

儿茶酚-O-甲基转移酶（COMT）通过甲基化使儿茶酚雌激素失活，因此可能对雌激素代谢物诱导的突变起保护作用。在这项研究中，我们在叙利亚进行了一项基于人群的病例对照研究，调查了 COMT 基因中的 Val58Met 多态性与乳腺癌风险之间的关系。

方法

我们在北叙利亚检查了 135 名乳腺癌患者和 107 名健康对照者，以确定 COMT 基因中功能性遗传 Val158Met 多态性与女性乳腺癌风险之间的关系。

结果

COMT 基因型与个体乳腺癌易感性之间无显著总体相关性。

结论

我们的数据表明，COMT 基因型与乳腺癌之间可能没有总体关联。

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