香烟烟雾可激活鸟苷酸环化酶并增加组织中3',5'-环磷酸鸟苷的含量。
Cigarette smoke activates guanylate cyclase and increases guanosine 3',5'-monophosphate in tissues.
作者信息
Arnold W P, Aldred R, Murad F
出版信息
Science. 1977 Dec 2;198(4320):934-6. doi: 10.1126/science.22126.
PMID:22126
Abstract
The gaseous phase of cigarette smoke induced a 2- to 36-fold increase in the activity of guanylate cyclase in supernatant and particulate fractions from various rat and bovine tissues over basal activity. The characteristics of this phenomenon paralleled those of the activation of guanylate cyclase by nitric oxide, which is a component of tobacco smoke.
摘要
香烟烟雾的气相成分使来自各种大鼠和牛组织的上清液和微粒部分中的鸟苷酸环化酶活性比基础活性增加了2至36倍。这种现象的特征与一氧化氮（烟草烟雾的一种成分）激活鸟苷酸环化酶的特征相似。
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