Izmirli Muzeyyen, Inandiklioglu Nihal, Abat Deniz, Alptekin Davut, Demirhan Osman, Tansug Zuhtu, Bayazit Yildirim
Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Asian Pac J Cancer Prev. 2011;12(7):1833-5.
Bladder cancer is the 9th most common cancer and is responsible for malignancy related death all on the world. Folate and folate related enzyme polymorphisms related to the cancer risk. The methylene tethrahydrofolate reductase (MTHFR) enzyme is folate related and association of bladder cancer and MTHFR gene. Our purpose was to assess the prevalence of MTHFR gene 677 CT and 1298 AC polymorphisms and Bladder cancer in Turkey. We intended that bladder cancer patients and controls and we used the Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods. The MTHFR gene C677T and A1298C polymorphisms were associated with an increased risk of bladder cancer in our population (For the MTHFR gene C677T polymorphism and A1298C polymorphism; p=0.036<0.05; p=0.278>0.05 respectively). Consequently, the MTHFR gene C677T polymorphism augments the risk of bladder cancer in Turkey.
膀胱癌是全球第九大常见癌症，也是导致恶性肿瘤相关死亡的原因之一。叶酸及与叶酸相关的酶多态性与癌症风险相关。亚甲基四氢叶酸还原酶（MTHFR）是一种与叶酸相关的酶，它与膀胱癌及MTHFR基因存在关联。我们的目的是评估土耳其人群中MTHFR基因677CT和1298AC多态性以及膀胱癌的患病率。我们选取了膀胱癌患者和对照组，并采用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）方法。在我们的研究人群中，MTHFR基因C677T和A1298C多态性与膀胱癌风险增加相关（对于MTHFR基因C677T多态性和A1298C多态性，p值分别为0.036<0.05；0.278>0.05）。因此，MTHFR基因C677T多态性增加了土耳其人群患膀胱癌的风险。
