Gemeinschaftspraxis für Strahlentherapie Singen-Friedrichshafen, Friedrichshafen, Germany.
Strahlenther Onkol. 2011 Dec;187(12):812-9. doi: 10.1007/s00066-011-2263-1. Epub 2011 Nov 29.
To compare plan quality criteria and dosimetric accuracy of step-and-shoot intensity-modulated radiotherapy (ss-IMRT) and volumetric modulated arc radiotherapy (VMAT) using two different gantry rotation times.
This retrospective planning study based on 20 patients was comprised of 10 prostate cancer (PC) and 10 head and neck (HN) cancer cases. Each plan contained two target volumes: a primary planning target volume (PTV) and a boost volume. For each patient, one ss-IMRT plan and two VMAT plans at 90 s (VMAT90) and 120 s (VMAT120) per arc were generated with the Pinnacle© planning system. Two arcs were provided for the PTV plans and a single arc for boost volumes. Dosimetric verification of the plans was performed using a 2D ionization chamber array placed in a full scatter phantom.
VMAT reduced delivery time and monitor units for both treatment sites compared to IMRT. VMAT120 vs. VMAT90 increased delivery time and monitor units in PC plans without improving plan quality. For HN cases, VMAT120 provided comparable organs at risk sparing and better target coverage and conformity than VMAT90. In the VMAT plan verification, an average of 97.1% of the detector points passed the 3 mm, 3% γ criterion, while in IMRT verification it was 98.8%.
VMAT90, VMAT120, and IMRT achieved comparable treatment plans. Slower gantry movement in VMAT120 plans only improves dosimetric quality for highly complex targets.
比较两种不同机架旋转时间的步进式强度调制放射治疗(ss-IMRT)和容积旋转调强放疗(VMAT)的计划质量标准和剂量学准确性。
这项回顾性计划研究基于 20 名患者,包括 10 例前列腺癌(PC)和 10 例头颈部(HN)癌症病例。每个计划包含两个靶区:一个主要计划靶区(PTV)和一个加量靶区。对于每个患者,使用 Pinnacle© 计划系统生成一个 ss-IMRT 计划和两个 VMAT 计划,即 90 秒(VMAT90)和 120 秒(VMAT120)每弧。PTV 计划提供两个弧,加量靶区提供一个弧。使用放置在全散射体模中的二维电离室阵列对计划进行剂量验证。
与 IMRT 相比,VMAT 降低了两个治疗部位的治疗时间和监测单位。与 VMAT90 相比,VMAT120 增加了 PC 计划的治疗时间和监测单位,但并未改善计划质量。对于 HN 病例,VMAT120 提供了可比的危及器官保护和更好的靶区覆盖和适形度,优于 VMAT90。在 VMAT 计划验证中,平均有 97.1%的探测器点通过了 3mm、3%γ标准,而在 IMRT 验证中为 98.8%。
VMAT90、VMAT120 和 IMRT 实现了可比的治疗计划。VMAT120 计划中较慢的机架运动仅能改善高度复杂靶区的剂量学质量。